Background Observational studies have found adiponectin inversely associated with
cardiovascular disease thereby indicating a potential target of intervention, but genetically …

Background Genetic variants, underlining phenotypic diversity, are known to distribute
unevenly in the human genome. A comprehensive understanding of the distributions of …

Aims Clinical and epidemiological findings point to an association between type 2 diabetes
(T2D) and osteoporosis. Genome-wide association studies (GWASs) have been fruitful in …

Variants in the CNNM2 gene are causative for hypomagnesaemia, seizures and intellectual
disability, although the phenotypes can be variable. This study aims to understand the …

ATXN2 gene, encoding for ataxin-2, is located in a trait locus for obesity. Atxn2 knockout
(KO) mice are obese and insulin resistant; however, the cause for this phenotype is still …

Background Although genome-wide association studies (GWAS) have been extensively
applied in identifying SNP associated with metabolic diseases, the SNPs identified by this …

Genome-wide association studies (GWASs) have identified hundreds of single nucleotide
polymorphisms (SNPs) associated with type 2 diabetes (T2D) and coronary artery disease …

Childhood obesity remains one of the most important issues in global health, which is
implicated in many chronic diseases. Converging evidence suggests that a higher body …

Obesity-related traits have been associated with coronary artery disease (CAD) in
observational studies, but these associations may be biased by confounding factors and …

Although genome-wide association studies (GWAS) have a dramatic impact on susceptibility
locus discovery, this univariate approach has limitations in detecting complex genotype …