[HTML][HTML] Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

J Ma, Y Li, X Yang, K Liu, X Zhang, X Zuo… - Signal transduction and …, 2023 - nature.com
Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

[HTML][HTML] Nrf2: a dark horse in doxorubicin-induced cardiotoxicity

X Zhao, Z Tian, M Sun, D Dong - Cell death discovery, 2023 - nature.com
Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment.
Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle …

Butyrate drives metabolic rewiring and epigenetic reprogramming in human colon cancer cells

L Wang, AAF Shannar, R Wu, P Chou… - Molecular nutrition & …, 2022 - Wiley Online Library
Scope Butyrate (B) is a short‐chain fatty acid produced by dietary fiber, known to inhibit
histone deacetylases (HDACs) and possess cancer‐preventive/anticancer effects. However …

Gut microbiota bridges the iron homeostasis and host health

L Xiao, R Tang, J Wang, D Wan, Y Yin, L Xie - Science China Life …, 2023 - Springer
The gut microbiota acts as a symbiotic microecosystem that plays an indispensable role in
the regulation of a number of metabolic processes in the host by secreting secondary …

[HTML][HTML] Histone demethylases in the regulation of immunity and inflammation

L Qu, T Yin, Y Zhao, W Lv, Z Liu, C Chen, K Liu… - Cell Death …, 2023 - nature.com
Pathogens or danger signals trigger the immune response. Moderate immune response
activation removes pathogens and avoids excessive inflammation and tissue damage …

Triterpenoid ursolic acid drives metabolic rewiring and epigenetic reprogramming in treatment/prevention of human prostate cancer

S Li, R Wu, L Wang, HC Dina Kuo… - Molecular …, 2022 - Wiley Online Library
Ursolic acid (UA) is a triterpenoid phytochemical with a strong anticancer effect. The
metabolic rewiring, epigenetic reprogramming, and chemopreventive effect of UA in prostate …

Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease …

W Rungratanawanich, JW Ballway, X Wang… - Pharmacology & …, 2023 - Elsevier
Epigenetic regulation is a process that takes place through adaptive cellular pathways
influenced by environmental factors and metabolic changes to modulate gene activity with …

Skeletal muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men

K Papanikolaou, AZ Jamurtas, A Poulios… - European Journal of …, 2023 - Springer
Purpose To investigate the association between redox status in erythrocytes and skeletal
muscle with dietary nutrient intake and markers of physical fitness and habitual physical …

[HTML][HTML] Integration of epigenetic mechanisms into non-genotoxic carcinogenicity hazard assessment: Focus on DNA methylation and histone modifications

D Desaulniers, P Vasseur, A Jacobs… - International Journal of …, 2021 - mdpi.com
Epigenetics involves a series of mechanisms that entail histone and DNA covalent
modifications and non-coding RNAs, and that collectively contribute to programing cell …

Tobacco carcinogen 4-[methyl (nitroso) amino]-1-(3-pyridinyl)-1-butanone (NNK) drives metabolic rewiring and epigenetic reprograming in A/J mice lung cancer …

RR Hudlikar, D Sargsyan, D Cheng, HCD Kuo… - …, 2022 - academic.oup.com
Early detection of biomarkers in lung cancer is one of the best preventive strategies.
Although many attempts have been made to understand the early events of lung …