Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

J Ren, NN Wu, S Wang, JR Sowers… - Physiological …, 2021 - journals.physiology.org
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Obesity as a multisystem disease: Trends in obesity rates and obesity‐related complications

S Sarma, S Sockalingam, S Dash - Diabetes, Obesity and …, 2021 - Wiley Online Library
Obesity is a chronic multisystem disease associated with increased morbidity and mortality.
The increasing prevalence of obesity makes it a major healthcare challenge across both …

Aldosterone synthase inhibition with lorundrostat for uncontrolled hypertension: the target-HTN randomized clinical trial

LJ Laffin, D Rodman, JM Luther, A Vaidya, MR Weir… - Jama, 2023 - jamanetwork.com
Importance Excess aldosterone production contributes to hypertension in both classical
hyperaldosteronism and obesity-associated hypertension. Therapies that reduce …

[HTML][HTML] Obesity and obesity-induced inflammatory disease contribute to atherosclerosis: a review of the pathophysiology and treatment of obesity

RJ Henning - American journal of cardiovascular disease, 2021 - ncbi.nlm.nih.gov
Two billion people worldwide older than 18 years of age, or approximately 30% of the world
population, are overweight or obese. In addition, more than 43 million children under the …

Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium

M Packer - Journal of the American College of Cardiology, 2018 - jacc.org
Epicardial adipose tissue has unique properties that distinguish it from other depots of
visceral fat. Rather than having distinct boundaries, the epicardium shares an unobstructed …

Impact of epicardial adipose tissue on cardiovascular haemodynamics, metabolic profile, and prognosis in heart failure

NR Pugliese, F Paneni, M Mazzola… - European journal of …, 2021 - Wiley Online Library
Aims We evaluated the impact of echocardiographic epicardial adipose tissue (EAT) on
cardiovascular haemodynamics, metabolic profile and prognosis in heart failure (HF) using …

Evaluation of the effects of sodium–glucose co‐transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a …

SD Anker, J Butler, GS Filippatos… - European journal of …, 2019 - Wiley Online Library
Background The principal biological processes that characterize heart failure with a
preserved ejection fraction (HFpEF) are systemic inflammation, epicardial adipose tissue …

Obesity and the obesity paradox in heart failure

TB Horwich, GC Fonarow, AL Clark - Progress in cardiovascular diseases, 2018 - Elsevier
Obesity continues to be a public health problem in the general population, and also
significantly increases the risk for the development of new-onset heart failure (HF). However …

The continuous heart failure spectrum: moving beyond an ejection fraction classification

F Triposkiadis, J Butler, FM Abboud… - European heart …, 2019 - academic.oup.com
Randomized clinical trials initially used heart failure (HF) patients with low left ventricular
ejection fraction (LVEF) to select study populations with high risk to enhance statistical …

Cardiovascular Aging and Heart Failure: JACC Review Topic of the Week

F Triposkiadis, A Xanthopoulos, J Butler - Journal of the American College …, 2019 - jacc.org
Heart failure (HF) is a clinical syndrome that usually develops in the elderly. Complex
interactions of the cardiovascular aging process with risk factors (obesity, hypertension, and …