Neuropathic pain, a maladaptive and chronic condition that can develop after a lesion or
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …

Current deficiency in our understanding of acute-to-chronic pain transition remains a hurdle
for developing effective treatments against chronic pain. Whereas neurocentric mechanisms …

Chronic musculoskeletal pain affects all aspects of human life. However, mechanisms of its
genetic control remain poorly understood. Genetic studies of pain are complicated by the …

Cross-modal plasticity is the repurposing of brain regions associated with deprived sensory
inputs to improve the capacity of other sensory modalities. The functional mechanisms of …

Neuropathic pain is a pathological symptom experienced worldwide by patients suffering
with nervous system dysfunction caused by various diseases. Treatment of neuropathic pain …

Palmitoylethanolamide (PEA) is an endogenous lipid modulator in animals and humans,
and has been evaluated since the 1970s as an anti-inflammatory and analgesic drug in …

Cardiac dysfunction with progressive inflammation and fibrosis is a hallmark of Chagas
disease caused by persistent Trypanosoma cruzi infection. Osteopontin (OPN) is a pro …

Matrix metalloproteinases (MMPs) are a large family of zinc-dependent proteolytic enzymes
associated with extracellular matrix protein turnover and tissue degradation. They participate …

Temporomandibular disorder (TMD) is characterized by acute or chronic orofacial pain,
which can be associated with inflammatory processes in the temporomandibular joint (TMJ) …

Taxane-induced peripheral neuropathy (TIPN) is a devastating survivorship issue for many
cancer patients. In addition to its impact on quality of life, this toxicity may lead to dose …