The strong genetic association between particular HLA alleles and type 1 diabetes (T1D)
indicates a key role for CD4+ T cells in disease; however, the differentiation state of the …

This article seeks to determine whether factors related to autoimmunity risk remain
significant after the initiation of two or more diabetes-related autoantibodies and continue to …

Aims/hypothesis The aim of this study was to develop strategies that identify children from
the general population who have late-stage presymptomatic type 1 diabetes and may …

OBJECTIVE Assessment of the predictive power of The Environmental Determinants of
Diabetes in the Young (TEDDY)-identified risk factors for islet autoimmunity (IA), the type of …

We examined the association between plasma 25-hydroxyvitamin D [25 (OH) D]
concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms …

Importance The incidence of diabetes in childhood has increased during the COVID-19
pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity …

OBJECTIVE The first-appearing β-cell autoantibody has been shown to influence risk of type
1 diabetes (T1D). Here, we assessed the risk of autoantibody spreading to the second …

The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively
follows 8,677 children enrolled from birth who carry HLA-susceptibility genotypes for …

OBJECTIVE Genetic risk scores (GRS) aid classification of diabetes type in White European
adult populations. We aimed to assess the utility of GRS in the classification of diabetes type …

Aims/hypothesis Young children who develop multiple autoantibodies (mAbs) are at very
high risk for type 1 diabetes. We assessed whether a population with mAbs detected by …