Islet Autoantibody Standardization Program: interlaboratory comparison of insulin autoantibody assay performance in 2018 and 2020 workshops

I Marzinotto, DL Pittman, AJK Williams, AE Long… - Diabetologia, 2023 - Springer
Abstract Aims/hypothesis The Islet Autoantibody Standardization Program (IASP) aims to
improve the performance of immunoassays measuring autoantibodies in type 1 diabetes …

Burden of cardiovascular risk factors over time and arterial stiffness in youth with type 1 diabetes mellitus: the SEARCH for diabetes in youth study

EM Urbina, S Isom, RA Bell, DA Bowlby… - Journal of the …, 2019 - Am Heart Assoc
Background The incidence of type 1 diabetes mellitus (T1DM) in children is increasing,
resulting in higher burden of cardiovascular diseases due to diabetes mellitus–related …

Reversion of β-cell autoimmunity changes risk of type 1 diabetes: TEDDY study

K Vehik, KF Lynch, DA Schatz, B Akolkar… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE β-Cell autoantibodies are a feature of the preclinical phase of type 1 diabetes.
Here, we asked how frequently they revert in a cohort of children at risk for type 1 diabetes …

Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort

V Bravis, A Kaur, HC Walkey, IF Godsland, S Misra… - BMJ open, 2018 - bmjopen.bmj.com
Objectives To describe the characteristics of children and adults with incident type 1
diabetes in contemporary, multiethnic UK, focusing on differences between the islet …

Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes

Q Zhang, TL Fillmore, AA Schepmoes… - Journal of Experimental …, 2013 - rupress.org
Using global liquid chromatography-mass spectrometry (LC-MS)–based proteomics
analyses, we identified 24 serum proteins that were significantly variant between those with …

Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention

A Michels, L Zhang, A Khadra, JA Kushner… - Pediatric …, 2015 - Wiley Online Library
Type 1 diabetes mellitus (T1DM) is the archetypal example of a T cell‐mediated
autoimmune disease characterized by selective destruction of pancreatic β cells. The …

[HTML][HTML] Harmonization of immunoassays for biomarkers in diabetes mellitus

S Hörber, P Achenbach, E Schleicher, A Peter - Biotechnology advances, 2020 - Elsevier
Harmonization of biomarkers is important for the comparability of laboratory results as it
allows the definition of universal reference values and clinical decision limits. In diabetology …

Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes

M Pietropaolo, R Towns… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Type 1 diabetes mellitus (T1D) is an autoimmune disease encompassing the T-cell-
mediated destruction of pancreatic β cells and the production of autoantibodies against islet …

Immune therapy in type 1 diabetes mellitus

Å Lernmark, HE Larsson - Nature Reviews Endocrinology, 2013 - nature.com
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder directed against the β cells of
the pancreatic islets. The genetic risk of the disease is linked to HLA-DQ risk alleles and …

Early infant diet and islet autoimmunity in the TEDDY study

U Uusitalo, HS Lee, C Andrén Aronsson… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE To examine duration of breastfeeding and timing of complementary foods and
risk of islet autoimmunity (IA). RESEARCH DESIGN AND METHODS The Environmental …