Sequential data mining of infection patterns as predictors for onset of type 1 diabetes in genetically at-risk individuals
Infections are implicated in the etiology of type 1 diabetes mellitus (T1DM); however,
conflicting epidemiologic evidence makes designing effective strategies for presymptomatic …
conflicting epidemiologic evidence makes designing effective strategies for presymptomatic …
The implications of autoantibodies to a single islet antigen in relatives with normal glucose tolerance: development of other autoantibodies and progression to type 1 …
PJ Bingley, DC Boulware, JP Krischer… - Diabetologia, 2016 - Springer
Aims/hypothesis Autoantibodies directed at single islet autoantigens are associated with
lower overall risk of type 1 diabetes than multiple autoantibodies, but individuals with one …
lower overall risk of type 1 diabetes than multiple autoantibodies, but individuals with one …
Time-resolved autoantibody profiling facilitates stratification of preclinical type 1 diabetes in children
Progression to clinical type 1 diabetes varies among children who develop β-cell
autoantibodies. Differences in autoantibody patterns could relate to disease progression …
autoantibodies. Differences in autoantibody patterns could relate to disease progression …
Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis
A Galderisi, C Giannini, R Weiss, G Kim… - The Lancet Child & …, 2018 - thelancet.com
Background Type 2 diabetes is preceded by a prediabetic stage of impaired glucose
tolerance that affects 10–23% of youth and is expected to double over the next decade. The …
tolerance that affects 10–23% of youth and is expected to double over the next decade. The …
Identical and nonidentical twins: risk and factors involved in development of islet autoimmunity and type 1 diabetes
OBJECTIVE There are variable reports of risk of concordance for progression to islet
autoantibodies and type 1 diabetes in identical twins after one twin is diagnosed. We …
autoantibodies and type 1 diabetes in identical twins after one twin is diagnosed. We …
Rising incidence of type 1 diabetes is associated with altered immunophenotype at diagnosis
The incidence of type 1 diabetes has increased rapidly over recent decades, particularly in
young children. We aimed to determine whether this rise was associated with changes in …
young children. We aimed to determine whether this rise was associated with changes in …
Characterising the age-dependent effects of risk factors on type 1 diabetes progression
M So, C O'Rourke, A Ylescupidez, HT Bahnson… - Diabetologia, 2022 - Springer
Aims/hypothesis Age is known to be one of the most important stratifiers of disease
progression in type 1 diabetes. However, what drives the difference in rate of progression …
progression in type 1 diabetes. However, what drives the difference in rate of progression …
Prediction and prevention of Type 1 diabetes mellitus
L Zhang, GS Eisenbarth - Journal of diabetes, 2011 - Wiley Online Library
Type 1A diabetes mellitus (T1DM) is caused by autoimmune islet β‐cell destruction with
consequent severe insulin deficiency. We can now predict the development of T1DM by …
consequent severe insulin deficiency. We can now predict the development of T1DM by …
Residual beta‐cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls
AK Steck, HE Larsson, X Liu, R Veijola… - Pediatric …, 2017 - Wiley Online Library
Objective To explore whether children diagnosed with type 1 diabetes during islet
autoantibody surveillance through The Environmental Determinants of Diabetes in the …
autoantibody surveillance through The Environmental Determinants of Diabetes in the …
Orbital fibrosis in a mouse model of Graves' disease induced by genetic immunization of thyrotropin receptor cDNA
SX Zhao, S Tsui, A Cheung… - The Journal of …, 2011 - joe.bioscientifica.com
The TSH receptor (TSHR) is the critical target for antibody production in Graves' disease
(GD). Insulin-like growth factor 1 receptor (IGF1R) has been proposed as a second …
(GD). Insulin-like growth factor 1 receptor (IGF1R) has been proposed as a second …