Family planning considerations in people with multiple sclerosis

KM Krysko, R Dobson, R Alroughani… - The Lancet …, 2023 - thelancet.com
Multiple sclerosis is often diagnosed in patients who are planning on having children.
Although multiple sclerosis does not negatively influence most pregnancy outcomes, less is …

[HTML][HTML] Monoclonal antibodies in the treatment of relapsing multiple sclerosis: an overview with emphasis on pregnancy, vaccination, and risk management

N Krajnc, G Bsteh, T Berger, J Mares, HP Hartung - Neurotherapeutics, 2022 - Elsevier
Monoclonal antibodies have become a mainstay in the treatment of patients with relapsing
multiple sclerosis (RMS) and provide some benefit to patients with primary progressive MS …

Multiple sclerosis disease activity and disability following discontinuation of natalizumab for pregnancy

K Hellwig, M Tokic, S Thiel, N Esters… - JAMA network …, 2022 - jamanetwork.com
Importance The magnitude of risk of pregnancy-related multiple sclerosis relapses,
particularly severe relapses, following natalizumab cessation is unclear, as is whether this …

[HTML][HTML] Use of natalizumab in persons with multiple sclerosis: 2022 update

SA Morrow, F Clift, V Devonshire, E Lapointe… - Multiple Sclerosis and …, 2022 - Elsevier
Background Natalizumab is a humanized monoclonal antibody used for treatment of highly
active relapsing-remitting multiple sclerosis (MS). With more than 15 years of post-marketing …

Anti-CD20 therapies in pregnancy and breast feeding: a review and ABN guidelines

R Dobson, D Rog, C Ovadia, K Murray, S Hughes… - Practical …, 2023 - pn.bmj.com
Neurologists increasingly use anti-CD20 therapies, including for women of childbearing
age, despite these medications being unlicensed for use in pregnancy. Current evidence …

Pregnancy management in multiple sclerosis and other demyelinating diseases

RM Bove, MK Houtchens - CONTINUUM: Lifelong Learning in …, 2022 - journals.lww.com
PURPOSE OF REVIEW Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders
(NMOSDs) are chronic autoimmune demyelinating conditions of the central nervous system …

Updated perspectives on the challenges of managing multiple sclerosis during pregnancy

R Villaverde-González - Degenerative Neurological and …, 2022 - Taylor & Francis
Multiple sclerosis (MS) is a chronic immune-mediated, inflammatory, and degenerative
disease that is up to three times more frequent in young women. MS does not alter fertility …

Drug and neurofilament levels in serum and breastmilk of women with multiple sclerosis exposed to natalizumab during pregnancy and lactation

U Proschmann, R Haase, H Inojosa, K Akgün… - Frontiers in …, 2021 - frontiersin.org
Objective To determine the transfer of the monoclonal antibody natalizumab into breastmilk
and to evaluate drug and serum neurofilament light chain ((s) NfL) levels in natalizumab …

Multiple sclerosis and pregnancy: Pathogenesis, influencing factors, and treatment options

Y Wang, J Wang, J Feng - Autoimmunity Reviews, 2023 - Elsevier
Multiple sclerosis (MS) is an autoimmune-mediated degenerative disease of the central
nervous system, characterized by inflammatory demyelination. It is primarily found in women …

Multiple sclerosis disease activity and disability following cessation of fingolimod for pregnancy

K Hellwig, M Tokic, S Thiel, S Hemat… - Neurology …, 2023 - AAN Enterprises
Background and Objective Discontinuation of fingolimod≥ 2 months before pregnancy is
recommended to minimize potential teratogenicity. The magnitude of MS pregnancy relapse …