Staphylococcus aureus infection is a major public health threat in part due to the spread of
antibiotic resistance and repeated failures to develop a protective vaccine. Infection is …

Background An essential fact underlying the severity of Staphylococcus aureus (S. aureus)
infection is the bicomponent leukocidins released by the pathogen to target and lyse host …

Nicotinamide adenine dinucleotide phosphate (NADPH) is the primary electron donor for
reductive reactions that are essential for the biosynthesis of major cell components in all …

A growing number of receptors, often associated with the innate immune response, are
being identified as targets for bacterial toxins of the beta‐stranded pore‐forming family …

许多病原菌能产生溶血素溶解红细胞, 但近年发现细菌溶血素还能损伤或致死多种有核细胞和
血小板. 根据分子结构, 结合细胞方式, 膜孔道形成机制等不同, 可将大多数细菌溶血素分类为 …

Staphylococcal bi-component pore-forming toxins, also known as leukocidins, target and
lyse human phagocytes in a receptor-dependent manner. S-components of the leukocidins …

Objectives Staphylococcus aureus produces up to five bi-component leukocidins–LukSF-
PV, gamma-hemolysins AB and CB, LukGH (LukAB) and LukED–to evade innate immunity …

MRSA (Methicillin-resistant Staphylococcus aureus) is the second-leading cause of deaths
by antibiotic-resistant bacteria globally, with more than 100,000 attributable deaths annually …

The complement anaphylatoxin C5a contributes to host defense against Staphylococcus
aureus. In this study, we investigated the functional role of the two known C5a receptors …

Staphylococcus aureus is a common pathogen capable of infecting both humans and
animals and causing various severe diseases. Here, we aimed to determine the biological …