Application of asymmetric Sharpless aminohydroxylation in total synthesis of natural products and some synthetic complex bio-active molecules

MM Heravi, TB Lashaki, B Fattahi, V Zadsirjan - RSC advances, 2018 - pubs.rsc.org
This report illustrates the applications of Asymmetric Sharpless Aminohydroxylation (ASAH)
in the stereoselective synthesis of vicinal amino alcohols as important intermediates in the …

Research progress in the biological activities of 3, 4, 5-trimethoxycinnamic acid (TMCA) derivatives

Z Zhao, H Song, J Xie, T Liu, X Zhao, X Chen… - European journal of …, 2019 - Elsevier
Abstract TMCA (3, 4, 5-trimethoxycinnamic acid) ester and amide are privileged structural
scaffolds in drug discovery which are widely distributed in natural products and …

Galantamine based novel acetylcholinesterase enzyme inhibitors: A molecular modeling design approach

LB Silva, EFB Ferreira, Maryam, JM Espejo-Román… - Molecules, 2023 - mdpi.com
Acetylcholinesterase (AChE) enzymes play an essential role in the development of
Alzheimer's disease (AD). Its excessive activity causes several neuronal problems …

In vitro antiplasmodial efficacy of synthetic coumarin-triazole analogs

N Yadav, D Agarwal, S Kumar, AK Dixit… - European Journal of …, 2018 - Elsevier
Twenty two diverse coumarin-triazole derivatives were synthesized by alkylation of 7-
hydroxy-4-methyl-coumarin followed by click chemistry at 7-position. These compounds …

Design and synthesis of eugenol/isoeugenol glycoconjugates and other analogues as antifungal agents against Aspergillus fumigatus

L Goswami, L Gupta, S Paul, M Vermani… - RSC Medicinal …, 2022 - pubs.rsc.org
Glycoconjugates are biologically significant molecules as they tend to serve a wide range of
intra-and extra-cellular processes depending on their size and complexity. The secondary …

Exploring the Pharmacological Potentials of Biosurfactant Derived from Planococcus maritimus SAMP MCC 3013

S Waghmode, S Swami, D Sarkar, M Suryavanshi… - Current …, 2020 - Springer
Therapeutic potential of biosurfactant (BS) has been improved in recent years. Our present
study deals with production of BS from Planococcus maritimus SAMP MCC 3013 in a …

Cobalt-Catalyzed Asymmetric Hydrosilylation of α-Oxygenated Ketones

H Wen, Y Chen, L Shi, J Chen, Y Luo, Y Xia - Organic Letters, 2023 - ACS Publications
An asymmetric hydrosilylation of α-oxygenated ketones was developed under the catalysis
of Co (OAc) 2 in combination with a chiral phosphine-amido-oxazoline (PAO) ligand …

Structure-guided regulation in the enantioselectivity of an epoxide hydrolase to produce enantiomeric monosubstituted epoxides and vicinal diols via kinetic resolution

D Hu, BC Hu, XD Hou, D Zhang, YQ Lei, YJ Rao… - Organic …, 2022 - ACS Publications
Structure-guided microtuning of an Aspergillus usamii epoxide hydrolase was executed.
One mutant, A214C/A250I, displayed a 12.6-fold enhanced enantiomeric ratio (E= 202) …

Enantioselective synthesis of vicinal diols by an enzymatic approach

Z Ju, M Li, FE Chen - Molecular Catalysis, 2024 - Elsevier
Chiral vicinal diols are crucial scaffolds frequently used for the preparation of adrenomimetic
drugs. Biotransformation of benzaldehyde is one of the most effective strategies to access …

Organic precursors for tailored synthesis of sulfur-and nitrogen-doped mesoporous carbons: a molecular design approach

T Hamada, H Nara, M Kim, H Miyata… - Chemical …, 2024 - pubs.rsc.org
Insights into tailoring heteroatom-doped mesoporous carbon are provided for enhanced
electrocatalytic properties. This study focuses on the design and synthesis of sulfur-doped …