Cancer-associated microbiota: from mechanisms of disease causation to microbiota-centric anti-cancer approaches

P Dey, S Ray Chaudhuri - Biology, 2022 - mdpi.com
Simple Summary Tissue-resident microbiota has been attributed to the overall human health
and disease. This comprehensive review summarizes the current understanding of how …

Astragaloside IV antagonizes M2 phenotype macrophage polarization-evoked ovarian cancer cell malignant progression by suppressing the HMGB1–TLR4 axis

X Wang, SY Gao, LY Song, M Liu, ZQ Sun, JB Liu - Molecular immunology, 2021 - Elsevier
Macrophages are the most abundant cells in tumor stroma and their polarization within
tumor microenvironment exert the key roles in tumorigenesis. Astragaloside IV is a natural …

Current understanding of microbiomes in cancer metastasis

J Liu, F Luo, L Wen, Z Zhao, H Sun - Cancers, 2023 - mdpi.com
Simple Summary Microbiomes, inhabiting multiple parts of the human body, are considered
to be associated with the progress, treatment, and prognosis of cancer. Metastasis is a main …

Gastric cancer tumor microenvironment characterization reveals stromal-related gene signatures associated with macrophage infiltration

S Wei, J Lu, J Lou, C Shi, S Mo, Y Shao, J Ni… - Frontiers in …, 2020 - frontiersin.org
The tumor microenvironment (TME) has attracted attention owing to its essential role in
tumor initiation, progression, and metastasis. With the emergence of immunotherapies for …

Toll like receptors as sensors of the tumor microbial dysbiosis: implications in cancer progression

V Le Noci, G Bernardo, F Bianchi… - Frontiers in Cell and …, 2021 - frontiersin.org
The microbiota is a complex ecosystem of active microorganisms resident in the body of
mammals. Although the majority of these microorganisms resides in the distal …

Circulating tumour cells in gastrointestinal cancers: food for thought?

S Asawa, M Nüesch, A Gvozdenovic… - British Journal of Cancer, 2023 - nature.com
Gastrointestinal (GI) cancers account for 35% of cancer-related deaths, predominantly due
to their ability to spread and generate drug-tolerant metastases. Arising from different …

Biofilm Potentiates Cancer‐Promoting Effects of Tumor‐Associated Macrophages in a 3D Multi‐Faceted Tumor Model

Y Deng, Y Fu, SL Chua, BL Khoo - Small, 2023 - Wiley Online Library
Components of the tumor microenvironment (TME), such as tumor‐associated macrophages
(TAMs), influence tumor progression. The specific polarization and phenotypic transition of …

Biliary diseases from the microbiome perspective: how microorganisms could change the approach to benign and malignant diseases

C Binda, G Gibiino, C Coluccio, M Sbrancia, E Dajti… - Microorganisms, 2022 - mdpi.com
Recent evidence regarding microbiota is modifying the cornerstones on pathogenesis and
the approaches to several gastrointestinal diseases, including biliary diseases. The burden …

Immunotherapeutic implications of toll-like receptors activation in tumor microenvironment

R Zheng, J Ma - Pharmaceutics, 2022 - mdpi.com
Toll-like receptors (TLRs) play an important role between innate and adaptive immunity as
one of the pattern recognition receptors (PRRs). Both immune cells and tumor cells express …

Variations in the gut microbiota in breast cancer occurrence and bone metastasis

Y Wenhui, X Zhongyu, C Kai, C Zhaopeng… - Frontiers in …, 2022 - frontiersin.org
Breast cancer is the most common cancer in women and the second most common cancer
overall. Although advancements in the early diagnosis and therapy of breast cancer have …