The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

[HTML][HTML] Multisystem inflammatory syndrome in children and Kawasaki disease: a critical comparison

C Sharma, M Ganigara, C Galeotti, J Burns… - Nature Reviews …, 2021 - nature.com
Children and adolescents infected with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are predominantly asymptomatic or have mild symptoms compared with the …

COVID-19 and liver disease: mechanistic and clinical perspectives

T Marjot, GJ Webb, AS Barritt IV, AM Moon… - Nature reviews …, 2021 - nature.com
Our understanding of the hepatic consequences of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection and its resultant coronavirus disease 2019 (COVID …

Risk factors for severe and critically ill COVID‐19 patients: a review

Y Gao, M Ding, X Dong, J Zhang, A Kursat Azkur… - Allergy, 2021 - Wiley Online Library
The pandemic of coronavirus disease 2019 (COVID‐19), caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused an unprecedented global …

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

DE Leisman, L Ronner, R Pinotti, MD Taylor… - The Lancet …, 2020 - thelancet.com
The description of a so-called cytokine storm in patients with COVID-19 has prompted
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However …

COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

MK Nadim, LG Forni, RL Mehta, MJ Connor Jr… - Nature reviews …, 2020 - nature.com
Kidney involvement in patients with coronavirus disease 2019 (COVID-19) is common, and
can range from the presence of proteinuria and haematuria to acute kidney injury (AKI) …

SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates

GA Poland, IG Ovsyannikova, RB Kennedy - The Lancet, 2020 - thelancet.com
Understanding immune responses to severe acute respiratory syndrome coronavirus 2 is
crucial to understanding disease pathogenesis and the usefulness of bridge therapies, such …

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

ES Winkler, AL Bailey, NM Kafai, S Nair… - Nature …, 2020 - nature.com
Although animal models have been evaluated for severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease …

A dynamic COVID-19 immune signature includes associations with poor prognosis

AG Laing, A Lorenc, I Del Molino Del Barrio, A Das… - Nature medicine, 2020 - nature.com
Improved understanding and management of COVID-19, a potentially life-threatening
disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward …

COVID-19 and multisystem inflammatory syndrome in children and adolescents

L Jiang, K Tang, M Levin, O Irfan, SK Morris… - The Lancet Infectious …, 2020 - thelancet.com
As severe acute respiratory syndrome coronavirus 2 continues to spread worldwide, there
have been increasing reports from Europe, North America, Asia, and Latin America …