Cancer stem cell functions in hepatocellular carcinoma and comprehensive therapeutic strategies

YC Liu, CT Yeh, KH Lin - Cells, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is a significant cause of cancer-related mortality owing to
resistance to traditional treatments and tumor recurrence after therapy, which leads to poor …

IL-6/STAT3 is a promising therapeutic target for hepatocellular carcinoma

J Xu, H Lin, G Wu, M Zhu, M Li - Frontiers in oncology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is a common malignant tumor of which the occurrence and
development, the tumorigenicity of HCC is involving in multistep and multifactor interactions …

Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma

V Hernandez–Gea, S Toffanin, SL Friedman, JM Llovet - Gastroenterology, 2013 - Elsevier
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and the third
greatest cause of cancer-related death worldwide, and its incidence is increasing. Despite …

STAT3 target genes relevant to human cancers

RL Carpenter, HW Lo - Cancers, 2014 - mdpi.com
Since its discovery, the STAT3 transcription factor has been extensively studied for its
function as a transcriptional regulator and its role as a mediator of development, normal …

[HTML][HTML] Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment

V Vilchez, L Turcios, F Marti… - World journal of …, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death
worldwide. Liver cancer is generally related to hepatitis B or C infection and cirrhosis …

Cancer stem cells in the development of liver cancer

T Yamashita, XW Wang - The Journal of clinical …, 2013 - Am Soc Clin Investig
Liver cancer is an aggressive disease with a poor outcome. Several hepatic stem/progenitor
markers are useful for isolating a subset of liver cells with stem cell features, known as …

Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis

X Wang, W Sun, W Shen, M Xia, C Chen, D Xiang… - Journal of …, 2016 - Elsevier
Background & Aims Emerging evidence has demonstrated the aberrant expression of long
non-coding RNAs (lncRNAs) in various malignancies including HCC. However, the …

[HTML][HTML] Common stemness regulators of embryonic and cancer stem cells

C Hadjimichael, K Chanoumidou… - World journal of stem …, 2015 - ncbi.nlm.nih.gov
Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Circular RNA cFAM210A, degradable by HBx, inhibits HCC tumorigenesis by suppressing YBX1 transactivation

J Yu, W Li, G Hou, D Sun, Y Yang, S Yuan… - … & Molecular Medicine, 2023 - nature.com
Hepatitis B protein x (HBx) has been reported to promote tumorigenesis in hepatitis B virus
(HBV)-related hepatocellular carcinoma (HCC), but the mechanism awaits further …

Potential role of signal transducer and activator of transcription (STAT) 3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular …

A Subramaniam, MK Shanmugam, E Perumal… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies, and is also the
fourth most common cancer worldwide with around 700,000 new cases each year …