Mitochondria play a key role in determining cell fate during exposure to stress. Their role
during ischemia/reperfusion is particularly critical because of the conditions that promote …

Mitochondria play a central role in energy metabolism within the cell. Mitochondrial
dysfunctions lead to various neurodegenerative disorders and to the so-called …

The critical time for opening mitochondrial (mito) KATP channels, putative end effectors of
ischemic preconditioning (PC), was examined. In isolated rabbit hearts 29±3% of risk zone …

Background Preconditioning by volatile anesthetics is a promising therapeutic strategy to
render myocardial tissue resistant to perioperative ischemia. It was hypothesized that …

ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …

Coronary artery disease and its sequelae—ischemia, myocardial infarction, and heart failure—
are leading causes of morbidity and mortality in man. Considerable effort has been devoted …

Nitric oxide (NO) participates in the control of contractility and heart rate, limits cardiac
remodeling after an infarction and contributes to the protective effect of ischemic pre-and …

We are on the brink of harnessing the cell's natural defenses against ischemia and
reperfusion injury after years of research into the destructive and protective mechanisms …

Adenosine (Ado) accumulates in tissues under metabolic stress. On myocardial cells, the
nucleoside interacts with various receptor subtypes (A1, A3, and probably A2A and A2B) …

1. Ischemic preconditioning and its endpoints morphological protection, while on the other
hand caution should be used when extrapolating findings from short-Brief episodes of …