Potassium channels that are inhibited by internal ATP (KATP channels) provide a critical link
between metabolism and cellular excitability. Protein kinase C (PKC) acts on KATP …

The mitochondrial ATP-dependent K+ channel (mitoKATP) is widely considered by many to
play a central role in cardioprotection by ischemic and pharmacological preconditioning and …

Objectives: Adaptation of rats to intermittent high altitude hypoxia increases the tolerance of
their hearts to acute ischemia/reperfusion injury. Our aim was to examine the role of …

Ischemia and reperfusion (I/R) cause a reduction in arterial blood supply to tissues, followed
by the restoration of perfusion and consequent reoxygenation. The reestablishment of blood …

We tested the hypothesis whether calcium preconditioning (CPC) reduces reoxygenation
injury by inhibiting mitochondrial permeability transition (MPT). Cultured myocytes were …

We showed recently that mitochondrial ATP-dependent K+ channel (mitoKATP) opening is
required for the inotropic response to ouabain. Because mitoKATP opening is also required …

Pharmacological studies indicate that Na+-H+ exchanger isoform 1 (NHE1) plays a central
role in myocardial ischemia-reperfusion injury; however, confirmation by alternative methods …

Ischemic tolerance decreases with aging and the cardioprotective effect of ischemic
preconditioning (IPC) is impaired in aged animals. Although lifelong caloric restriction (CR) …

Whether the mitochondrial ATP-dependent potassium (mKATP) channel is the trigger or the
mediator of cardioprotection is controversial. We investigated the critical time sequences of …

Nitric oxide (NO) has been implicated in the ««second-window»» of ischemic
preconditioning (PC). However, the identity of the end effector after initiation of …