Ischemia-reperfusion injury is an important cause of liver damage occurring during surgical
procedures including hepatic resection and liver transplantation, and represents the main …

Inflammation In the absence of pathogens occurs in all tissues in response to a wide range
of stimuli that cause tissue stress and injury. Such sterile inflammation (SI) is a key process …

Hepatic ischemia/reperfusion (I/R) injury is a major complication of liver surgery, including
liver resection, liver transplantation, and trauma surgery. Much has been learned about the …

Blood circulating from the intestines to the liver is rich in bacterial products, environmental
toxins, and food antigens. To effectively and quickly defend against potentially toxic agents …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Liver ischemia/reperfusion (IR) injury is typified by an inflammatory response.
Understanding the cellular and molecular events underpinning this inflammation is …

Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic
transplantation, hepatic resection, and trauma. The signaling events contributing to local …

Liver ischemia reperfusion activates innate immune system to drive the full development of
inflammatory hepatocellular injury. Damage-associated molecular patterns (DAMPs) …

The proinflammatory cytokine interleukin (IL)-1 signals exclusively through the type I IL-1
receptor (IL-1RI). IL-1 expression is markedly induced in the infarcted heart; however, its role …

The NLRP3 inflammasome is activated in response to a variety of signals that are indicative
of damage to the host including tissue damage, metabolic stress, and infection. Upon …