This book presents 55 clinical cases emphasizing the basic science aspects of pathology
and is “the closest you can get to the wards without seeing patients.” Each case includes an …

Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …

Peripheral inflammation, defined as inflammation that occurs outside the central nervous
system, is an age-related phenomenon that has been identified as a risk factor for …

Extravasation is the first step for nanomedicines in circulation to reach targeted solid tumors.
Traditional nanomedicines have been designed to extravasate into tumor interstitium …

Emerging evidence suggests that the meningeal compartment plays instrumental roles in
various neurological disorders, however, we still lack fundamental knowledge about …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the
coronavirus disease (COVID-19), is currently infecting millions of people worldwide and is …

The NLRP3 inflammasome is a vital part of the innate immune response, whilst its aberrant
activation drives the progression of a number of non-communicable diseases. Thus, NLRP3 …

Alzheimer's disease (AD) is the most common cause of dementia and there is currently no
cure. Novel approaches to treat AD and curb the rapidly increasing worldwide prevalence …

The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …

Three different barriers are formed between the cerebrovascular and the brain parenchyma:
the blood-brain barrier (BBB), the blood-cerebrospinal fluid barrier (BCSFB), and the …