Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …

Gene expression is tremendously altered in the brain during memory acquisition, recall, and
forgetfulness. However, non-genetic factors, including environmental elements, epigenetic …

Importance People who complete more education live longer lives with better health. New
evidence suggests that these benefits operate through a slowed pace of biological aging. If …

Objectives Individuals with more education are at lower risk of developing multiple, different
age-related diseases than their less-educated peers. A reason for this might be that …

Epigenetic clocks can measure aging and predict the incidence of diseases and mortality.
Higher levels of physical fitness are associated with a slower aging process and a healthier …

Health problems associated with aging are a major public health concern for the future.
Aging is a complex process with wide intervariability among individuals. Therefore, there is a …

Background A decade ago, we proposed an index of physiological dysregulation based on
Mahalanobis distance (DM) that measures how far from the norm an individual biomarker …

Chronological age (CA) may not accurately reflect the health status of an individual. Rather,
biological age (BA) or hypothetical underlying “functional” age has been proposed as a …

Epigenetic clocks based on DNA methylation have been known as biomarkers of aging,
including principal component (PC) clocks representing the degree of aging and …

Background Epigenetic clocks were known as promising biomarkers of aging, including
original clocks trained by individual CpG sites and principal component (PC) clocks trained …