Cancer cells frequently display fundamentally altered cellular metabolism, which provides
the biochemical foundation and directly contributes to tumorigenicity and malignancy …

The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …

Essential fatty acids can serve as important regulators of inflammation. A new window into
mechanisms for the resolution of inflammation was opened with the identification and …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Over one hundred different phospholipid molecular species are known to be present in
mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including …

Among more than 30 members of the phospholipase A 2 (PLA 2) superfamily, secreted PLA
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …

C-reactive protein (CRP) is the best-known acute phase protein. In humans, almost every
type of inflammation is accompanied by an increase of CRP concentration. Until recently, the …

Extracellular vesicles (EVs), such as exosomes and microvesicles, are small membrane-
bound vesicles released by cells under various conditions. In a multitude of physiological …

Abstract Phospholipase A 2 (PLA 2) cleave phospholipids preferentially at the sn-2 position,
liberating free fatty acids and lysophospholipids. They are classified into six main groups …

Acute pancreatitis is a disease associated with suffering and high lethality. Although the
disease mechanism is unclear, phospholipase A2 (PLA2) produced by pancreatic acinar …