Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue
culture artefact by some researchers, senescence is now a major field of study. Although …

A well-functioning immune system of the host body plays pivotal role in the maintenance of
ordinary physiological and immunological functions as well as internal environment …

Diffuse intrinsic pontine glioma (DIPG) remains a fatal brainstem tumor demanding
innovative therapies. As B7-H3 (CD276) is expressed on central nervous system (CNS) …

The decline in hematopoietic function seen during aging involves a progressive reduction in
the immune response and an increased incidence of myeloid malignancy, and has been …

Microglia, the primary resident immune cells of the central nervous system (CNS), exhibit
dynamic behavior involving rapid process motility and cellular migration that is thought to …

Patients with infective endocarditis (IE) form a heterogeneous group, ranging from those
who are successfully treated with no adverse events, to those with severe complications and …

Purpose To provide recent data on patient demographics, clinical profile and outcomes of
patients with microbial keratitis over a 5-year period at the Sydney Eye Hospital, and to …

Cryopyrin-associated periodic syndrome (CAPS) is caused by gain-of-function NLRP3
mutations. Recently, somatic NLRP3 mosaicism has been reported in some CAPS patients …

Age-related changes in the hematopoietic compartment are primarily attributed to cell-
intrinsic alterations in hematopoietic stem cells (HSCs); however, the contribution of the …

Telomeres, repetitive DNA sequences found at the ends of linear chromosomes, play a role
in regulating cellular proliferation, and shorten with increasing age in proliferating human …