Patient-specific iPSC-derived astrocytes contribute to non-cell-autonomous neurodegeneration in Parkinson's disease
A di Domenico, G Carola, C Calatayud… - Stem cell reports, 2019 - cell.com
Parkinson's disease (PD) is associated with the degeneration of ventral midbrain
dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell …
dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell …
Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013 …
CJL Murray, RM Barber, KJ Foreman, AA Ozgoren… - The Lancet, 2015 - thelancet.com
Summary Background The Global Burden of Disease Study 2013 (GBD 2013) aims to bring
together all available epidemiological data using a coherent measurement framework …
together all available epidemiological data using a coherent measurement framework …
Efficacy and safety of intranasal esketamine adjunctive to oral antidepressant therapy in treatment-resistant depression: a randomized clinical trial
EJ Daly, JB Singh, M Fedgchin, K Cooper, P Lim… - JAMA …, 2018 - jamanetwork.com
Importance Approximately one-third of patients with major depressive disorder (MDD) do not
respond to available antidepressants. Objective To assess the efficacy, safety, and dose …
respond to available antidepressants. Objective To assess the efficacy, safety, and dose …
[HTML][HTML] Reassessing the host defense peptide landscape
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
A global view of pulmonary hypertension
Pulmonary hypertension is a substantial global health issue. All age groups are affected with
rapidly growing importance in elderly people, particularly in countries with ageing …
rapidly growing importance in elderly people, particularly in countries with ageing …
Diabetes in sub-Saharan Africa: from clinical care to health policy
Executive summary Rapid demographic, sociocultural, and economic transitions are driving
increases in the risk and prevalence of diabetes and other non-communicable diseases …
increases in the risk and prevalence of diabetes and other non-communicable diseases …
Global prevalence of chronic kidney disease–a systematic review and meta-analysis
Chronic kidney disease (CKD) is a global health burden with a high economic cost to health
systems and is an independent risk factor for cardiovascular disease (CVD). All stages of …
systems and is an independent risk factor for cardiovascular disease (CVD). All stages of …
Individual differences in pain: understanding the mosaic that makes pain personal
RB Fillingim - Pain, 2017 - journals.lww.com
It has long been appreciated that individuals differ from each other in important ways. More
than 2000 years ago, Plato said:“No 2 persons are born exactly alike; but each differs from …
than 2000 years ago, Plato said:“No 2 persons are born exactly alike; but each differs from …
Has increased provision of treatment reduced the prevalence of common mental disorders? Review of the evidence from four countries
Many people identified as having common mental disorders in community surveys do not
receive treatment. Modelling has suggested that closing this “treatment gap” should reduce …
receive treatment. Modelling has suggested that closing this “treatment gap” should reduce …
Disability weights for the Global Burden of Disease 2013 study
Summary Background The Global Burden of Disease (GBD) study assesses health losses
from diseases, injuries, and risk factors using disability-adjusted life-years, which need a set …
from diseases, injuries, and risk factors using disability-adjusted life-years, which need a set …