Organic cation transporters (OCTs) of the solute carrier family (SLC) 22 and multidrug and
toxin extrusion (MATE) transporters of the SLC47 family have been identified as uptake and …

Platinum-based drugs are among the most active anticancer agents and are successfully
used in a wide variety of human malignancies. However, acquired and/or intrinsic resistance …

Glucuronidation is a well-recognized phase II metabolic pathway for a variety of chemicals
including drugs and endogenous substances. Although it is usually the secondary metabolic …

Organic anion-transporting polypeptides (OATPs) are multispecific transporters that mediate
the uptake of numerous drugs and xenobiotics into cells. Here, we examined the effect of …

Nine proteins of the ABC superfamily (P-glycoprotein, 7 MRPs and BCRP) are involved in
multidrug transport. Being localised at the surface of endothelial or epithelial cells, they …

Eleven members of the human organic anion transporter (OATP) family (grouped into six
families) facilitate the Na+-independent transmembrane transport of various endo-and …

renal elimination of a number of cationic compounds is thought to be mediated by the
organic cation transporter 2 (OCT2, SLC22A2), a drug uptake transporter expressed at the …

Green tea catechins inhibit the function of organic anion transporting polypeptides (OATPs)
that mediate the uptake of a diverse group of drugs and endogenous compounds into cells …

Drugs and their metabolites are eliminated mainly by excretion into urine and bile. Studies in
whole animals, isolated organs, cells, and membrane vesicles led to the conclusion that …

Organic anion transporting polypeptides (OATP, SLCO genes) mediate the uptake of
endobiotics and drugs. Thus, their expression levels and pattern could be of relevance for …