Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of
therapy resistance is a hot topic in epigenetics. As one of the most common RNA …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Mitochondrial dysfunction and glycolysis activation are improtant hallmarks of hepatocellular
carcinoma (HCC). NOP2 is an S-adenosyl-L-methionine-dependent methyltransferase that …

Background Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in the
world, with a high likelihood of metastasis and a dismal prognosis. The reprogramming of …

High-grade astrocytoma with piloid features (HGAP) is a recently recognized glioma type
whose classification is dependent on its global epigenetic signature. HGAP is characterized …

Ferroptosis is a form of programmed cell death characterized by elevated intracellular
ferrous ion levels and increased lipid peroxidation. Since its discovery and characterization …

Tumor angiogenesis plays vital roles in the growth and metastasis of cancer. RNA
methylation is one of the most common modifications and is widely observed in eukaryotes …

Background Cuproptosis, a novel cell death caused by excess copper, is quite obscure in
hepatocellular carcinoma (HCC) and needs more investigation. Methods RNA-seq and …

Methylation of RNA plays an important role in cancer. Classical forms of such modifications
include N6-methyladenine (m6A), 5-methylcytosine (m5C), and N1-methyladenine (m1A) …

Background Mitochondria are significant both for cellular energy production and reactive
oxygen/nitrogen species formation. However, the significant functions of mitochondrial …