Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

Emerging evidence indicates that gut microbiota is important in the regulation of brain
activity and cognitive functions. Microbes mediate communication among the metabolic …

Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …

Alzheimer's disease (AD) is a neurodegenerative disease that causes memory and cognitive
decline. Although many studies have attempted to clarify the causes of AD occurrence, it is …

Gut microbiome disturbances have been widely implicated in major depressive disorder
(MDD), although the identity of causal microbial species and the underlying mechanisms are …

Chronic stress constitutes a major risk factor for depression that can disrupt various aspects
of homeostasis, including the gut microbiome (GM). We have recently shown that GM …

Testosterone deficiency can lead to depressive symptoms in humans; however, the causes
of this deficiency are incompletely understood. Here, we isolated Mycobacterium neoaurum …

The emergence of the coronavirus disease 2019 pandemic has dramatically increased the
global prevalence of depression. Unfortunately, antidepressant drugs benefit only a small …

The spleen, an important tissue for the immune system, acts as a filter for blood within the
immune system. Accumulating evidence suggests that the spleen affects a number of brain …