Revisiting the neurovascular unit

S Schaeffer, C Iadecola - Nature neuroscience, 2021 - nature.com
The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

Blood–brain barrier breakdown: an emerging biomarker of cognitive impairment in normal aging and dementia

B Hussain, C Fang, J Chang - Frontiers in neuroscience, 2021 - frontiersin.org
The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

Pericyte control of blood flow across microvascular zones in the central nervous system

DA Hartmann, V Coelho-Santos… - Annual review of …, 2022 - annualreviews.org
The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …

Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders

M Martin, S Vermeiren, N Bostaille, M Eubelen… - Science, 2022 - science.org
The blood-brain barrier (BBB) protects the central nervous system (CNS) from harmful blood-
borne factors. Although BBB dysfunction is a hallmark of several neurological disorders …

Brain capillary pericytes exert a substantial but slow influence on blood flow

DA Hartmann, AA Berthiaume, RI Grant, SA Harrill… - Nature …, 2021 - nature.com
The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …

Pericytes in the disease spotlight

H van Splunder, P Villacampa, A Martínez-Romero… - Trends in Cell …, 2023 - cell.com
Pericytes are known as the mural cells in small-caliber vessels that interact closely with the
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …

Changing demography and the challenge of dementia in India

V Ravindranath, JS Sundarakumar - Nature Reviews Neurology, 2021 - nature.com
In India, increasing lifespan and decreasing fertility rates have resulted in a growing number
of older persons. By 2050, people over 60 years of age are predicted to constitute 19.1% of …

Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging

T Lindner, DS Bolar, E Achten, F Barkhof… - Magnetic resonance …, 2023 - Wiley Online Library
This article focuses on clinical applications of arterial spin labeling (ASL) and is part of a
wider effort from the International Society for Magnetic Resonance in Medicine (ISMRM) …

Single-cell analysis of blood-brain barrier response to pericyte loss

MA Mäe, L He, S Nordling… - Circulation …, 2021 - Am Heart Assoc
Rationale: Pericytes are capillary mural cells playing a role in stabilizing newly formed blood
vessels during development and tissue repair. Loss of pericytes has been described in …

Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex

E Gerrits, LAA Giannini, N Brouwer, S Melhem… - Nature …, 2022 - nature.com
Frontotemporal dementia (FTD) is the second most prevalent form of early-onset dementia,
affecting predominantly frontal and temporal cerebral lobes. Heterozygous mutations in the …