The evolution of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths and substantial morbidity worldwide. Intense scientific effort to understand the …
deaths and substantial morbidity worldwide. Intense scientific effort to understand the …
Analysis of SARS-CoV-2 mutations associated with resistance to therapeutic monoclonal antibodies that emerge after treatment.
D Focosi, S McConnell, DJ Sullivan… - Drug Resistance Updates, 2023 - Elsevier
The mutation rate of the Omicron sublineage has led to baseline resistance against all
previously authorized anti-Spike monoclonal antibodies (mAbs). Nevertheless, in case more …
previously authorized anti-Spike monoclonal antibodies (mAbs). Nevertheless, in case more …
SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency
Y Li, MC Choudhary, J Regan, J Boucau… - Science translational …, 2024 - science.org
Despite vaccination and antiviral therapies, immunocompromised individuals are at risk for
prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but the …
prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but the …
Clinical, genomic, and immunological characterization of RSV surge in Sydney, Australia, 2022
OBJECTIVES The 2022 seasonal respiratory syncytial virus (RSV) epidemic in Sydney,
Australia saw an unprecedented number of RSV detections. We aimed to characterize …
Australia saw an unprecedented number of RSV detections. We aimed to characterize …
A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection
Most neutralizing anti-SARS-CoV-2 monoclonal antibodies (mAbs) target the receptor
binding domain (RBD) of the spike (S) protein. Here, we characterize a panel of mAbs …
binding domain (RBD) of the spike (S) protein. Here, we characterize a panel of mAbs …
Making waves: integrating wastewater surveillance with dynamic modeling to track and predict viral outbreaks
Wastewater surveillance has proved to be a valuable tool to track the COVID-19 pandemic.
However, most studies using wastewater surveillance data revolve around establishing …
However, most studies using wastewater surveillance data revolve around establishing …
A randomized controlled study assessing convalescent immunoglobulins vs convalescent plasma for hospitalized patients with Coronavirus 2019
Y Maor, E Shinar, M Izak, G Rahav… - Clinical Infectious …, 2023 - academic.oup.com
Background It is unknown whether convalescent immunoglobulins (cIgGs) are better than
convalescent plasma (CP) for patients with coronavirus 2019 (COVID-19). Methods In this …
convalescent plasma (CP) for patients with coronavirus 2019 (COVID-19). Methods In this …
SARS-CoV-2 Monoclonal Antibody Treatment Followed by Vaccination Shifts Human Memory B-Cell Epitope Recognition, Suggesting Antibody Feedback
Therapeutic monoclonal antibodies (mAbs) have been studied in humans, but the impact on
immune memory of mAb treatment during an ongoing infection remains unclear. We …
immune memory of mAb treatment during an ongoing infection remains unclear. We …
Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody
To mitigate the loss of lives during the COVID-19 pandemic, emergency use authorization
was given to several anti-SARS-CoV-2 monoclonal antibody (mAb) therapies for the …
was given to several anti-SARS-CoV-2 monoclonal antibody (mAb) therapies for the …
COVID-19 therapeutics
Since the emergence of COVID-19 in 2020, an unprecedented range of therapeutic options
has been studied and deployed. Healthcare providers have multiple treatment approaches …
has been studied and deployed. Healthcare providers have multiple treatment approaches …