The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Q Zhang, R Xiang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback …

[HTML][HTML] Emerging variants of SARS-CoV-2 and novel therapeutics against coronavirus (COVID-19)

A Aleem, AS Ab, AK Slenker - 2021 - europepmc.org
Objectives: Describe the clinical manifestations, including extrapulmonary manifestations of
COVID-19. Outline the latest treatments available in the management of COVID-19 …

Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection

L Montefusco, M Ben Nasr, F D'Addio, C Loretelli… - Nature …, 2021 - nature.com
Patients with coronavirus disease 2019 (COVID-19) are reported to have a greater
prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute …

The SARS-CoV-2 as an instrumental trigger of autoimmunity

A Dotan, S Muller, D Kanduc, P David, G Halpert… - Autoimmunity …, 2021 - Elsevier
Autoimmunity may be generated by a variety of factors by creating a hyper-stimulated state
of the immune system. It had been established long ago that viruses are a substantial …

Risk factors for severe and critically ill COVID‐19 patients: a review

Y Gao, M Ding, X Dong, J Zhang, A Kursat Azkur… - Allergy, 2021 - Wiley Online Library
The pandemic of coronavirus disease 2019 (COVID‐19), caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused an unprecedented global …

Patients with COVID-19: in the dark-NETs of neutrophils

M Ackermann, HJ Anders, R Bilyy, GL Bowlin… - Cell Death & …, 2021 - nature.com
SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …

COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms

J Loo, DA Spittle, M Newnham - Thorax, 2021 - thorax.bmj.com
Thrombotic events that frequently occur in COVID-19 are predominantly venous
thromboemboli (VTE) and are associated with increasing disease severity and worse clinical …

[HTML][HTML] Features, evaluation, and treatment of coronavirus (COVID-19)

M Cascella, M Rajnik, A Aleem, SC Dulebohn… - Statpearls …, 2023 - ncbi.nlm.nih.gov
Objectives: Screen individuals based on exposure and symptom criteria to identify potential
COVID-19 cases. Identify the clinical features and radiological findings expected in patients …

[HTML][HTML] The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice

EM Rhea, AF Logsdon, KM Hansen, LM Williams… - Nature …, 2021 - nature.com
It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes
coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome …