Purpose The complex relationship between linear energy transfer (LET) and cellular
response to radiation is not yet fully elucidated. To better characterize DNA damage after …

Purpose Fibroblast growth factor receptor 2 (FGFR2) has been previously reported to be
overexpressed in several types of cancer, whereas the expression in normal tissue is …

Studies of the biological effects of ionizing radiation have shown that DNA is the primary
target of radiation in living systems. 1–3 The understanding of the physicochemical and …

Proper repair of DNA double-strand breaks is essential to the maintenance of genomic
stability and avoidance of genetic disease. Organisms have many ways of repairing double …

This study describes a method to validate a radiation transport model that quantifies the
number of DNA double-strand breaks (DSB) produced in the lymphocyte nucleus by internal …

64CuCl2 has recently been proposed as a promising agent for prostate cancer (PCa)
theranostics, based on preclinical studies in cellular and animal models, and on the …

Objectives: Gliclazide (GL) is widely used to reduce hyperglycemia in diabetic patients. The
aim of this study was to investigate the protective effect of GL against chromosome damage …

The quantitative detection of radiation caused DNA double-strand breaks (DSB) by
immunostained γ-H2AX foci using direct stochastic optical reconstruction microscopy …

The combination of several closely spaced DNA lesions, which can be induced by a single
radical hit, constitutes a hallmark in the DNA damage landscape and radiation chemistry …

Background DNA damage is generated by various intrinsic and extrinsic sources such as
reactive oxygen species (ROS) and environmental mutagens, and causes genomic …