Single-molecule localization microscopy as a promising tool for γH2AX/53BP1 foci exploration

D Depes, JH Lee, E Bobkova, L Jezkova… - The European Physical …, 2018 - Springer
Quantification and structural studies of DNA double strand breaks (DSBs) are an essential
part of radiobiology because DSBs represent the most serious damage introduced to the …

Molecular mechanisms associated with clustered lesion-induced impairment of 8-oxoG recognition by the human glycosylase OGG1

T Jiang, A Monari, E Dumont, E Bignon - Molecules, 2021 - mdpi.com
The 8-oxo-7, 8-dihydroguanine, referred to as 8-oxoG, is a highly mutagenic DNA lesion that
can provoke the appearance of mismatches if it escapes the DNA Damage Response. The …

Regulation of Precise DNA Repair by Nuclear Actin Polymerization: A Chance for Improving Gene Therapy?

X He, C Brakebusch - Cells, 2024 - mdpi.com
Although more difficult to detect than in the cytoplasm, it is now clear that actin
polymerization occurs in the nucleus and that it plays a role in the specific processes of the …

Role of SigB and Staphyloxanthin in Radiation Survival of Staphylococcus aureus

MK Pannu, DA Hudman, NJ Sargentini, VK Singh - Current microbiology, 2019 - Springer
Staphylococcus aureus is a potent human pathogen. The virulence of this bacterium
depends on a multitude of factors that it produces. One such virulence factor is the golden …

NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress

B Yang, DM Figueroa, Y Hou, M Babbar… - Free Radical Biology …, 2019 - Elsevier
Cellular exposure to ionizing radiation leads to oxidatively generated DNA damage, which
has been implicated in neurodegenerative diseases. DNA damage is repaired by the …

Radioresistance in rhabdomyosarcomas: Much more than a question of dose

S Camero, M Cassandri, S Pomella, L Milazzo… - Frontiers in …, 2022 - frontiersin.org
Management of rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in
children, frequently accounting the genitourinary tract is complex and requires a multimodal …

Understanding the radiobiology of vestibular schwannomas to overcome radiation resistance

TP Thielhelm, S Goncalves, SM Welford, EA Mellon… - Cancers, 2021 - mdpi.com
Simple Summary Vestibular schwannomas (VS) are intracranial tumors that originate from
the Schwann cells of the vestibulocochlear nerve and cause hearing loss and dizziness …

Recruitment Kinetics of XRCC1 and RNF8 Following MeV Proton and α-Particle Micro-Irradiation

G Muggiolu, E Torfeh, M Simon, G Devès, H Seznec… - Biology, 2023 - mdpi.com
Simple Summary We used the charged-particle microbeam installed at the AIFIRA facility to
perform micro-irradiation experiments and measure the recruitment kinetics of DNA …

Screening of pesticides with the potential of inducing DSB and successive recombinational repair

K Suárez-Larios, AM Salazar-Martínez… - Journal of …, 2017 - Wiley Online Library
A study was realized to ascertain whether eight selected pesticides would induce double
strand breaks (DSB) in lymphocyte cultures and whether this damage would induce greater …

Heavy ion mutagenesis combined with triclosan screening provides a new strategy for improving the arachidonic acid yield in Mortierella alpina

H Zhang, D Lu, X Li, Y Feng, Q Cui, X Song - BMC biotechnology, 2018 - Springer
Background Arachidonic acid (ARA), which is a ω-6 polyunsaturated fatty acid, has a wide
range of biological activities and is an essential component of cellular membranes in some …