Misregulated gene expression in human hearts can result in cardiovascular diseases that
are leading causes of mortality worldwide. However, the limited information on the genomic …

BACKGROUND Oocyte aging has significant clinical consequences, and yet no treatment
exists to address the age-related decline in oocyte quality. The lack of progress in the …

Osteoporotic fracture is among the most common and costly of diseases. While reasonably
heritable, its genetic determinants have remained elusive. Forearm fractures are the most …

The genetic architecture of human reproductive behavior—age at first birth (AFB) and
number of children ever born (NEB)—has a strong relationship with fitness, human …

Primary ovarian insufficiency (POI) is an uncommon yet devastating occurrence that results
from a premature depletion of the ovarian pool of primordial follicles. Our understanding of …

Importance Preclinical and epidemiological studies indicate a potential chemopreventive
role of statins in epithelial ovarian cancer risk. Objective To evaluate the association of …

Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

Background Observational studies have investigated the association of risk factors with
breast cancer prognosis. However, the results have been conflicting and it has been …

Preference for mates with similar phenotypes; that is, assortative mating, is widely observed
in humans,,,–and has evolutionary consequences,–. Under Fisher's classical theory …

Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Using
data from large endometriosis and EOC genome-wide association meta-analyses, we …