Primary ovarian insufficiency (POI) is defined by the loss or dysfunction of ovarian follicles
associated with amenorrhea before the age of 40. Symptoms include hot flashes, sleep …

The present study was designed to examine whether sex hormone polymorphisms proven
by GWAS are associated with endometriosis risk. Unrelated female participants totaling …

Reproductive ageing leading to menopause is characterized by depletion of follicles and its
regulating mechanisms are only partly understood. Early age at menopause and premature …

Fertility and pregnancy-related issues represent one of the main areas of concerns for young
women with breast cancer. Carrying a germline deleterious BRCA mutation adds additional …

Ovarian infertility and subfertility presenting with premature ovarian insufficiency (POI) and
diminished ovarian reserve are major issues facing the developed world due to the trend of …

The disease criteria used by the World Health Organization (WHO) were applied to human
biological aging in order to assess whether aging can be classified as a disease. These …

STUDY QUESTION Which genetic factors regulate female propensity for giving birth to
spontaneous dizygotic (DZ) twins? SUMMARY ANSWER We identified four new loci …

Menopause marks the end of the reproductive phase of life. Based on epidemiological
studies, abnormal age at natural menopause (ANM) is thought to contribute to a number of …

The transgenerational maternal effects of polycystic ovary syndrome (PCOS) in female
progeny are being revealed. As there is evidence that a male equivalent of PCOS may …

BACKGROUND The human female reproductive lifespan is regulated by the dynamics of
ovarian function, which in turn is influenced by several factors: from the basic molecular …