Abstract MicroRNAs (miRNAs) are~ 22 nt RNAs that coordinate vast regulatory networks in
animals and thereby influence myriad processes. This Review examines evidence that …

Emerging evidences suggest that necrosis is programmed and is one of the main forms of
cell death in the pathological process in cardiac diseases. Long noncoding RNAs (lncRNAs) …

Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …

The nervous system equips us with capability to adapt to many conditions and
circumstances. We rely on an armamentarium of intricately formed neural circuits for many of …

We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-
1R1/TLR4) innate immunity signal plays a pivotal role in neuronal hyperexcitability …

In many patients who suffer from epilepsies, recurrent epileptic seizures do not start at birth
but develop later in life. This holds particularly true for epilepsies with a focal seizure origin …

Epilepsy is a frequent neurological disorder, although onset and progression of seizures
remain difficult to predict in affected patients, irrespective of their epileptogenic condition …

Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene
expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to …

Background The expression pattern and function of miRNAs in the rat model of temporal
lobe epilepsy have not been well defined. Profiling miRNA expression in the rat model of …

Temporal lobe epilepsy is the most common and often devastating form of human epilepsy.
The molecular mechanism underlying the development of temporal lobe epilepsy remains …