Epilepsy therapy is based on drugs that treat the symptoms rather than the underlying
mechanisms of the disease (epileptogenesis). There are no treatments for preventing …

Mesial temporal lobe epilepsy (MTLE) is a particularly devastating form of human epilepsy
with significant incidence of medical intractability. MicroRNAs (miRs) are small, noncoding …

Fine-tuning of gene expression is a fundamental requirement for development and function
of cells and organs. This requirement is particularly obvious in the nervous system where …

The mechanisms generating epileptic neuronal networks following insults such as severe
seizures are unknown. We have previously shown that interfering with the function of the …

MicroRNAs (miRNAs) are small double-stranded RNAs that exert a fine-tuning sequence-
specific regulation of cell transcriptome. While one unique miRNA regulates hundreds of …

Perinatal hypoxic–ischemic encephalopathy (HIE) is associated with high neonatal mortality
and severe long-term neurologic morbidity. Yet the mechanisms of brain injury in infants with …

This article describes the recent advances in epileptogenesis and novel therapeutic
approaches for the prevention of epilepsy, with a special emphasis on the pharmacological …

To design potentially more effective therapies, we need to further understand the
mechanisms underlying epilepsy. Here, we uncover the role of Rev-erbα in circadian …

MicroRNA and epilepsy: profiling, functions and potential cl... : Current Opinion in Neurology
MicroRNA and epilepsy: profiling, functions and potential clinical applications : Current …

Background and Purpose Neonatal seizures represent a clinical emergency. However,
current anti‐seizure medications fail to resolve seizures in~ 50% of infants. The P2X7 …