Stress factors in protein drug product manufacturing and their impact on product quality

TK Das, A Sreedhara, JD Colandene, DK Chou… - Journal of …, 2022 - Elsevier
Injectable protein-based medicinal products (drug products, or DPs) must be produced by
using sterile manufacturing processes to ensure product safety. In DP manufacturing the …

The effect of COVID-19 on gut microbiota: Exploring the complex interplay and implications for human health

S Akter, S Tasnim, R Barua, M Choubey… - Gastrointestinal …, 2023 - mdpi.com
The COVID-19 pandemic caused by the SARS-CoV-2 virus has led to significant global
health implications. Although the respiratory manifestations of COVID-19 are widely …

Navigating the post-COVID-19 immunological era: understanding long COVID-19 and immune response

A Mohan, VA Iyer, D Kumar, L Batra, P Dahiya - Life, 2023 - mdpi.com
The COVID-19 pandemic has affected the world unprecedentedly, with both positive and
negative impacts. COVID-19 significantly impacted the immune system, and understanding …

Therapeutic prospects of ceRNAs in COVID-19

L Liu, Y Zhang, Y Chen, Y Zhao, J Shen… - Frontiers in Cellular …, 2022 - frontiersin.org
Since the end of 2019, COVID-19 caused by SARS-CoV-2 has spread worldwide, and the
understanding of the new coronavirus is in a preliminary stage. Currently, immunotherapy …

Promising Effects of 3-Month Period of Quercetin Phytosome® Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot …

M Rondanelli, S Perna, C Gasparri, G Petrangolini… - Life, 2022 - mdpi.com
Quercetin, for its crucial properties, fulfills the need for a multifactor action that is useful for
the potential counterbalance of a COVID-19 infection. Given this background, the aim of the …

Alkaloids in genus stephania (Menispermaceae): a comprehensive review of its ethnopharmacology, phytochemistry, pharmacology and toxicology

M Wang, XM Zhang, X Fu, P Zhang, WJ Hu… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Approximately 60 species of the genus Stephania
(Menispermaceae) are distributed worldwide. Among these, 39 species are located in South …

Pyroptosis and respiratory diseases: a review of current knowledge

J Sun, Y Li - Frontiers in Immunology, 2022 - frontiersin.org
Pyroptosis is a relatively newly discovered programmed cell death accompanied by an
inflammatory response. In the classical view, pyroptosis is mediated by caspases-1,-4,-5,-11 …

Development and management of gastrointestinal symptoms in long-term COVID-19

KY He, XY Lei, L Zhang, DH Wu, JQ Li, LY Lu… - Frontiers in …, 2023 - frontiersin.org
Background Emerging evidence reveals that SARS-CoV-2 possesses the capability to
disrupt the gastrointestinal (GI) homeostasis, resulting in the long-term symptoms such as …

The safety and efficacy of melatonin in the treatment of COVID-19: A systematic review and meta-analysis

XC Wang, GL Wu, YF Cai, SJ Zhang - Medicine, 2022 - journals.lww.com
Background: As an infectious disease caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the common signs of coronavirus disease 2019 (COVID-19) …

Current clinical status of new COVID-19 vaccines and immunotherapy

D Nagpal, S Nagpal, D Kaushik, H Kathuria - Environmental Science and …, 2022 - Springer
Abstract COVID-19, caused by SARS-CoV-2, is a positive-strand RNA belonging to
Coronaviridae family, along with MERS and SARS. Since its first report in 2019 in Wuhan …