Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

The practice of polypharmacology is not a new concept but the approaches which are being
adopted for administering the two or more drugs together are varied from time to time …

Quinoline and quinolone motifs which act as structural subunits of more complex natural
products are ubiquitous in nature, and they are useful pharmacophores which play a pivotal …

Compounds containing a 1, 1-diaryl motif are numerous, and compounds of this type have
found use as catalysts and molecular building blocks, however, this review focusses solely …

The application of quinoline-based compounds for the treatment of malaria infections is
hampered by drug resistance. Drug resistance has led to the combination of quinolines with …

Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …

Most antimalarials are based on basic N-heterocycles and possess amine functionalities.
Despite this, the role of basic nitrogen (BaN) in antimalarial drug design has not been …

Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …

Amongst several communicable diseases (CDs), malaria is one of the deadliest parasitic
disease all over the world, particularly in African and Asian countries. To curb this menace …

For the treatment of malaria which affects nearly 200 million people each year and the
continued exacerbation by the emergence of drug resistance to most of the available …