Prospective roles of tumor necrosis factor-alpha (TNF-α) in COVID-19: prognosis, therapeutic and management

Z Mohd Zawawi, J Kalyanasundram… - International journal of …, 2023 - mdpi.com
The coronavirus disease 2019 (COVID-19) became a worldwide concern at the beginning of
2020 and has affected millions. Several previous studies revealed the impact of the …

Efficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or …

EW Ely, AV Ramanan, CE Kartman… - The Lancet …, 2022 - thelancet.com
Summary Background The oral, selective Janus kinase 1/2 inhibitor baricitinib has shown
efficacy in studies of hospitalised adults with COVID-19. COV-BARRIER (NCT04421027) …

Inflammasomes and IL-1 family cytokines in SARS-CoV-2 infection: from prognostic marker to therapeutic agent

J Declercq, E De Leeuw, BN Lambrecht - Cytokine, 2022 - Elsevier
Despite global vaccination programs, infections with severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) continue to cause severe disease with significant morbidity …

Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline …

A Syenina, ES Gan, JZN Toh, R de Alwis, LZ Lin… - PLoS …, 2022 - journals.plos.org
Ensuring high vaccination and even booster vaccination coverage is critical in preventing
severe Coronavirus Disease 2019 (COVID-19). Among the various COVID-19 vaccines …

Pyroptosis in host defence against bacterial infection

D Brokatzky, S Mostowy - Disease Models & Mechanisms, 2022 - journals.biologists.com
Pyroptosis, a regulated form of pro-inflammatory cell death, is characterised by cell lysis and
by the release of cytokines, damage-and pathogen-associated molecular patterns. It plays …

Incidence of new-onset hypertension before, during, and after the COVID-19 pandemic: a 7-year longitudinal cohort study in a large population

V Trimarco, R Izzo, D Pacella, U Trama, MV Manzi… - BMC medicine, 2024 - Springer
Background While the augmented incidence of diabetes after COVID-19 has been widely
confirmed, controversial results are available on the risk of developing hypertension during …

SARS-CoV-2 infection relaxes peripheral B cell tolerance

MJ Castleman, MM Stumpf, NR Therrien… - Journal of Experimental …, 2022 - rupress.org
Severe SARS-CoV-2 infection is associated with strong inflammation and autoantibody
production against diverse self-antigens, suggesting a system-wide defect in B cell …

Regulated Arginine Metabolism in Immunopathogenesis of a Wide Range of Diseases: Is There a Way to Pass between Scylla and Charybdis?

EA Starikova, AA Rubinstein, JT Mammedova… - Current Issues in …, 2023 - mdpi.com
More than a century has passed since arginine was discovered, but the metabolism of the
amino acid never ceases to amaze researchers. Being a conditionally essential amino acid …

[HTML][HTML] Network pharmacology and molecular docking-based investigations of Kochiae Fructus's active phytomolecules, molecular targets, and pathways in treating …

SA Khan, TKW Lee - Frontiers in microbiology, 2022 - frontiersin.org
COVID-19 disease is caused by SARS-CoV-2. Hyper-inflammation mediated by
proinflammatory cytokines is humans' primary etiology of SARS-CoV-2 infection. Kochiae …

CXCR3 antagonist rescues ER stress and reduces inflammation and JEV infection in mice brain

A Singh, R Ghosh, P Guchhait - Cytokine, 2023 - Elsevier
The endoplasmic reticulum (ER) is crucial for maintaining cellular homeostasis, and
synthesis and folding of proteins and lipids. The ER is sensitive to stresses including viral …