Current approaches to malaria vaccines
PE Duffy - Current opinion in microbiology, 2022 - Elsevier
Highlights•First malaria vaccine RTS, S induces anti-sporozoite antibodies to protect
children.•Whole-sporozoite vaccines induce T cells and antibodies and confer field …
children.•Whole-sporozoite vaccines induce T cells and antibodies and confer field …
Designing an effective malaria vaccine targeting Plasmodium vivax Duffy-binding protein
Malaria caused by the Plasmodium vivax parasite is a major global health burden. Immunity
against blood-stage infection reduces parasitemia and disease severity. Duffy-binding …
against blood-stage infection reduces parasitemia and disease severity. Duffy-binding …
PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum
SW Scally, T Triglia, C Evelyn, BA Seager… - Nature …, 2022 - nature.com
The most severe form of malaria is caused by Plasmodium falciparum. These parasites
invade human erythrocytes, and an essential step in this process involves the ligand PfRh5 …
invade human erythrocytes, and an essential step in this process involves the ligand PfRh5 …
[HTML][HTML] The PfRCR complex bridges malaria parasite and erythrocyte during invasion
The symptoms of malaria occur during the blood stage of infection, when parasites invade
and replicate within human erythrocytes. The PfPCRCR complex, containing PfRH5 (refs.,) …
and replicate within human erythrocytes. The PfPCRCR complex, containing PfRH5 (refs.,) …
Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex
BG Williams, LDW King, D Pulido, D Quinkert… - Nature …, 2024 - nature.com
Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium
falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) …
falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) …
A critical review on human malaria and schistosomiasis vaccines: current state, recent advancements, and developments
Malaria and schistosomiasis are two major parasitic diseases that remain leading causes of
morbidity and mortality worldwide. Co-infections of these two parasites are common in the …
morbidity and mortality worldwide. Co-infections of these two parasites are common in the …
Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes
Basigin is an essential host receptor for invasion of Plasmodium falciparum into human
erythrocytes, interacting with parasite surface protein PfRH5. PfRH5 is a leading blood-stage …
erythrocytes, interacting with parasite surface protein PfRH5. PfRH5 is a leading blood-stage …
[HTML][HTML] The essential malaria protein PfCyRPA targets glycans to invade erythrocytes
Plasmodium falciparum is a human-adapted apicomplexan parasite that causes the most
dangerous form of malaria. P. falciparum cysteine-rich protective antigen (PfCyRPA) is an …
dangerous form of malaria. P. falciparum cysteine-rich protective antigen (PfCyRPA) is an …
RH5. 1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5. 1 in a preclinical setting
J Healer, JK Thompson, KL Mackwell… - Frontiers in Cellular …, 2022 - frontiersin.org
Background RH5 is the leading vaccine candidate for the Plasmodium falciparum blood
stage and has shown impact on parasite growth in the blood in a human clinical trial. RH5 …
stage and has shown impact on parasite growth in the blood in a human clinical trial. RH5 …
The malaria blood stage antigen PfCyRPA formulated with the TLR-4 agonist adjuvant GLA-SE elicits parasite growth inhibitory antibodies in experimental animals
M Tamborrini, A Schäfer, J Hauser, L Zou, DH Paris… - Malaria Journal, 2023 - Springer
Background Plasmodium falciparum cysteine-rich protective antigen (Pf CyRPA) is an
invasion complex protein essential for erythrocyte invasion. In contrast to several previously …
invasion complex protein essential for erythrocyte invasion. In contrast to several previously …