Mind how you go: The current strategies for the development of therapies for Alzheimer's
disease are very diverse. Particular attention is given to the search for inhibitors (see picture …

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …

N-linked glycosylation is a biologically important protein modification, but only a small
fraction of modification sites have been mapped. We developed a" filter aided sample …

Amyloid β-protein precursor (APP), a type I membrane protein, is cleaved by primary α-or β-
secretase and secondary γ-secretase. Cleavage of APP by β-and γ-secretases generates …

Vesicular transport proteins participate in various biological processes and play a significant
role in the movement of substances within cells. These proteins are associated with …

Budding yeast Saccharomyces cerevisiae has proven to be a valuable model organism for
studying fundamental cellular processes across the eukaryotic kingdom including man. In …

The pathogenesis of Alzheimer's disease (AD) is associated with proteolytic processing of
the amyloid precursor protein (APP) to an amyloidogenic peptide termed Aβ. Although …

Multiple synaptic adhesion molecules govern synapse formation. Here, we propose
calsyntenin-3/alcadein-β as a synapse organizer that specifically induces presynaptic …

The cholinotrophic system, which is dependent upon nerve growth factor and its receptors
for survival, is selectively vulnerable in Alzheimer's disease (AD). But, virtually nothing is …

Alzheimer's disease (AD) is the most common type of dementia, comprising 60− 80% of all
reported cases, and currently affects 5.2 million Americans. AD is characterized …