Salusins: potential use as a biomarker for atherosclerotic cardiovascular diseases

K Sato, R Watanabe, F Itoh, M Shichiri… - International journal …, 2013 - Wiley Online Library
Human salusin‐α and salusin‐β are related peptides produced from prosalusin. Bolus
injection of salusin‐β into rats induces more profound hypotension and bradycardia than …

[HTML][HTML] Neopterin derivatives–a novel therapeutic target rather than biomarker for atherosclerosis and related diseases

T Watanabe - Vasa, 2020 - econtent.hogrefe.com
This review provides an updated overview of the emerging roles of neopterin derivatives in
atherosclerosis. Neopterin, a metabolite of guanosine triphosphate, is produced by …

Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway

Z Zhu, J Li, X Zhang - BMC complementary and alternative medicine, 2019 - Springer
Background Atherosclerosis is a condition with the vascular accumulation of lipid plaques,
and its main major contributing factor is endothelial injury induced by oxidized low-density …

[HTML][HTML] Astragaloside IV protects against oxidized low-density lipoprotein (ox-LDL)-induced endothelial cell injury by reducing oxidative stress and inflammation

Z Zhu, J Li, X Zhang - … medical journal of experimental and clinical …, 2019 - ncbi.nlm.nih.gov
Background Endothelial injury is the main mechanism of atherosclerosis, and is caused by
oxidized low-density lipoprotein (ox-LDL). Astragaloside IV (AS-IV) is the primary active …

Neopterin counters vascular inflammation and atherosclerosis

R Shirai, K Sato, T Yamashita… - Journal of the …, 2018 - Am Heart Assoc
Background Neopterin, a metabolite of GTP, is produced by activated macrophages and is
abundantly expressed within atherosclerotic lesions in human aorta and carotid and …

Allicin prevents oxidized low-density lipoprotein-induced endothelial cell injury by inhibiting apoptosis and oxidative stress pathway

X Chen, S Pang, J Lin, J Xia, Y Wang - BMC complementary and …, 2016 - Springer
Background Vascular endothelial apoptosis is significantly associated with atherosclerosis
and cardiovascular diseases, for which oxidized low-density lipoprotein (ox-LDL) is a major …

Salusins: advance in cardiovascular disease research

M Chen, B Deng, S Liu, Z Wang… - Journal of Pharmacy and …, 2023 - academic.oup.com
Salusins are discovered in 2003 and divided into salusin-α and salusin-β, which are
bioactive peptides with hemodynamic and mitotic activity and mainly distributed in plasma …

Roles of the kisspeptin/GPR54 system in pathomechanisms of atherosclerosis

T Watanabe, K Sato - Nutrition, Metabolism and Cardiovascular Diseases, 2020 - Elsevier
Abstract Aims Kisspeptin-10 (KP-10), a potent vasoconstrictor and inhibitor of angiogenesis,
and its receptor, GPR54, have currently received much attention with respect to …

[HTML][HTML] CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and …

MH Tsai, CW Lee, LF Hsu, SY Li, YC Chiang, MH Lee… - Redox Biology, 2017 - Elsevier
Ang II has been involved in the pathogenesis of cardiovascular diseases, and matrix
metalloproteinase-9 (MMP-9) induced migration of human aortic smooth muscle cells …

Emerging roles of cardiotrophin-1 in the pathogenesis and biomarker of atherosclerosis

T Watanabe, H Konii, K Sato - J, 2018 - mdpi.com
Cardiotrophin-1 (CT-1), an interleukin-6 family cytokine, is known as an active inducer
capable of cardiac hypertrophy and vascular stiffness in hypertensive heart disease. CT-1 is …