The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …
devastating consequences. While the medical community has gained insight into the …
[HTML][HTML] Monocytes and Macrophages in COVID-19
COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing
pandemic with massive global health and socioeconomic consequences. The disease is …
pandemic with massive global health and socioeconomic consequences. The disease is …
[HTML][HTML] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection
SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …
[HTML][HTML] Immune senescence, immunosenescence and aging
With aging, there is increased dysfunction of both innate and adaptive immune responses,
which contributes to impaired immune responses to pathogens and greater mortality and …
which contributes to impaired immune responses to pathogens and greater mortality and …
Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19
Lung-infiltrating macrophages create a marked inflammatory milieu in a subset of patients
with COVID-19 by producing a cytokine storm, which correlates with increased lethality …
with COVID-19 by producing a cytokine storm, which correlates with increased lethality …
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19
Pediatric coronavirus disease 2019 (COVID-19) after SARS-CoV-2 infection is associated
with fewer hospitalizations and often milder disease than in adults. A subset of children …
with fewer hospitalizations and often milder disease than in adults. A subset of children …
[HTML][HTML] Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19
COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response
variation to disease severity and outcome over time, we longitudinally assessed circulating …
variation to disease severity and outcome over time, we longitudinally assessed circulating …
[HTML][HTML] Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae
RC Thompson, NW Simons, L Wilkins, E Cheng… - Nature Medicine, 2023 - nature.com
Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A …
infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A …
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort
The drivers of critical coronavirus disease 2019 (COVID-19) remain unknown. Given major
confounding factors such as age and comorbidities, true mediators of this condition have …
confounding factors such as age and comorbidities, true mediators of this condition have …
Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity
S Chakraborty, JC Gonzalez, BL Sievers… - Science Translational …, 2022 - science.org
A damaging inflammatory response is implicated in the pathogenesis of severe coronavirus
disease 2019 (COVID-19), but mechanisms contributing to this response are unclear. In two …
disease 2019 (COVID-19), but mechanisms contributing to this response are unclear. In two …