In osteosarcoma patients, metastasis of the primary cancer is the leading cause of death. At
present, management options to prevent metastasis are limited and non-curative. In this …

Osteosarcoma, originating from primitive bone-forming mesenchymal cells, is the most
common malignant bone tumour among children and adolescents. N6-methyladenosine …

OBJECTIVE: To explore whether fat mass and obesity associated proteins (FTO) is an
important target of Qiteng Xiaozhuo granules (QTXZG, 芪藤消浊颗粒) medicated serum in …

Osteosarcoma, a predominant malignant bone tumor, poses significant challenges due to its
high metastatic and recurrent nature. Although various therapeutic strategies are currently in …

Krüppel-like factors (KLFs) are a group of DNA-binding transcriptional regulators with
multiple essential functions in various cellular processes, including proliferation, migration …

Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system
with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 …

RNA methylation modifications are widespread in eukaryotes and prokaryotes, with N 6-
methyladenosine (m 6 A) the most common among them. Demethylases, including Fat mass …

Apoptosis, a highly controlled homeostatic mechanism that eliminates single cells without
destroying tissue function, occurs during growing development and senescence. N6 …

Background Krüppel-like factor 3 (KLF3) is a key transcriptional repressor, which is involved
in various biological functions such as lipogenesis, erythropoiesis, and B cell development …

Krüppel‐like factors (KLFs) are crucial in the development of bone disease. They are a
family of zinc finger transcription factors that are unusual in containing three highly …