The rapid transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has resulted to the death of hundreds of thousands of people worldwide. With the …

Peptide vaccination in cancer therapy is a promising alternative to conventional methods.
However, the parameters for this personalized treatment are difficult to access …

Population models are important tools for evaluating human impacts and potential
management approaches on declining species. However, often studies are limited by …

The Human Immune System (HIS) plays a fundamental role in the defense of the body
against diseases. However, the multi-scale interactions among several of its components …

Abstract Background Recent advances in Immunology highlighted the importance of local
properties on the overall progression of HIV infection. In particular, the gastrointestinal tract …

Predictive modelling of complex biological systems and biophysical interactions requires the
inclusion of multiple nano-and micro-scale events. In many scenarios, however, numerical …

Abstract Volumetric Muscle Loss (VML) injuries are characterized by significant loss of
muscle mass, usually due to trauma or surgical resection, often with a residual open wound …

Computational models of the immune system have several applications, such as theory
testing and validation, or as a complement to first stages of drug testing. The majority of …

This work describes the architecture of an agent based computer model that simulates the
autoimmune response in Type 1 diabetes in a three-dimensional cubic volume representing …

The complex differentiation process of the CD4+ T helper lymphocytes shapes the form and
the range of the immune response to different antigenic challenges. Few mathematical and …