RNA m6A methylation across the transcriptome
E Sendinc, Y Shi - Molecular cell, 2023 - cell.com
Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
[HTML][HTML] Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …
[HTML][HTML] Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation
The mechanistic understanding of nascent RNAs in transcriptional control remains limited.
Here, by a high sensitivity method methylation-inscribed nascent transcripts sequencing …
Here, by a high sensitivity method methylation-inscribed nascent transcripts sequencing …
Direct identification of A-to-I editing sites with nanopore native RNA sequencing
TA Nguyen, JWJ Heng, P Kaewsapsak, EPL Kok… - Nature …, 2022 - nature.com
Inosine is a prevalent RNA modification in animals and is formed when an adenosine is
deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly …
deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly …
[HTML][HTML] Taming transposable elements in vertebrates: from epigenetic silencing to domestication
Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …
known to date. Because their expression and mobility can lead to genomic instability …
The multifaceted effects of YTHDC1-mediated nuclear m6A recognition
N6-methyladenosine or m 6 A modification to mRNAs is now recognised as a key regulator
of gene expression and protein translation. The fate of m 6 A-modified mRNAs is decoded …
of gene expression and protein translation. The fate of m 6 A-modified mRNAs is decoded …
[HTML][HTML] CSTF2 mediated mRNA N6-methyladenosine modification drives pancreatic ductal adenocarcinoma m6A subtypes
Y Zheng, X Li, S Deng, H Zhao, Y Ye, S Zhang… - Nature …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) modification of gene transcripts plays critical roles in
cancer. Here we report transcriptomic m6A profiling in 98 tissue samples from 65 individuals …
cancer. Here we report transcriptomic m6A profiling in 98 tissue samples from 65 individuals …
m6A RNA demethylase AtALKBH9B promotes mobilization of a heat-activated long terminal repeat retrotransposon in Arabidopsis
Transposons are mobile and ubiquitous DNA molecules that can cause vast genomic
alterations. In plants, it is well documented that transposon mobilization is strongly …
alterations. In plants, it is well documented that transposon mobilization is strongly …
[HTML][HTML] Context-specific effects of sequence elements on subcellular localization of linear and circular RNAs
M Ron, I Ulitsky - Nature communications, 2022 - nature.com
Long RNAs vary extensively in their post-transcriptional fates, and this variation is attributed
in part to short sequence elements. We used massively parallel RNA assays to study how …
in part to short sequence elements. We used massively parallel RNA assays to study how …
[HTML][HTML] Autonomous transposons tune their sequences to ensure somatic suppression
Transposable elements (TEs) are a major constituent of human genes, occupying
approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs …
approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs …