DNA methylation aging clocks: challenges and recommendations

CG Bell, R Lowe, PD Adams, AA Baccarelli, S Beck… - Genome biology, 2019 - Springer
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

tRNA dysregulation and disease

EA Orellana, E Siegal, RI Gregory - Nature Reviews Genetics, 2022 - nature.com
Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …

Engineering triangular carbon quantum dots with unprecedented narrow bandwidth emission for multicolored LEDs

F Yuan, T Yuan, L Sui, Z Wang, Z Xi, Y Li, X Li… - Nature …, 2018 - nature.com
Carbon quantum dots (CQDs) have emerged as promising materials for optoelectronic
applications on account of carbon's intrinsic merits of high stability, low cost, and …

TwinsUK: the UK adult twin registry update

S Verdi, G Abbasian, RCE Bowyer… - Twin Research and …, 2019 - cambridge.org
TwinsUK is the largest cohort of community-dwelling adult twins in the UK. The registry
comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets); it is …

Epigenetic modification of nucleic acids: from basic studies to medical applications

Y Chen, T Hong, S Wang, J Mo, T Tian… - Chemical Society …, 2017 - pubs.rsc.org
The epigenetic modification of nucleic acids represents one of the most significant areas of
study in the field of nucleic acids because it makes gene regulation more complex and …

An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging

T Yuan, Y Jiao, S de Jong, RA Ophoff, S Beck… - PLoS …, 2015 - journals.plos.org
Recent studies have demonstrated that the DNA methylome changes with age. This
epigenetic drift may have deep implications for cellular differentiation and disease …

Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites

SM Tajuddin, DG Hernandez, BH Chen… - Clinical …, 2019 - Springer
Abstract Background African Americans (AAs) experience premature chronic health
outcomes and longevity disparities consistent with an accelerated aging phenotype. DNA …

The impact of caloric restriction on the epigenetic signatures of aging

N Gensous, C Franceschi, A Santoro… - International journal of …, 2019 - mdpi.com
Aging is characterized by an extensive remodeling of epigenetic patterns, which has been
implicated in the physiopathology of age-related diseases. Nutrition plays a significant role …

Genetic impacts on DNA methylation help elucidate regulatory genomic processes

S Villicaña, J Castillo-Fernandez, E Hannon… - Genome Biology, 2023 - Springer
Background Pinpointing genetic impacts on DNA methylation can improve our
understanding of pathways that underlie gene regulation and disease risk. Results We …

The relationships and interactions between age, exercise and physiological function

NR Lazarus, JM Lord… - The Journal of physiology, 2019 - Wiley Online Library
This brief review focuses on the relationships and interactions between human ageing,
exercise and physiological function. It explores the importance of the selection of …