Australian clinical practice guidelines for the diagnosis and management of B arrett's esophagus and early esophageal adenocarcinoma

DC Whiteman, M Appleyard, FF Bahin… - Journal of …, 2015 - Wiley Online Library
B arrett's esophagus (BE), a common condition, is the only known precursor to esophageal
adenocarcinoma (EAC). There is uncertainty about the best way to manage BE as most …

Barrett oesophagus: lessons on its origins from the lesion itself

SAC McDonald, D Lavery, NA Wright… - Nature reviews …, 2015 - nature.com
Barrett oesophagus develops when the lower oesophageal squamous epithelium is
replaced with columnar epithelium, which shows both intestinal and gastric differentiation …

Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus

HP Hahn, PL Blount, K Ayub, KM Das… - The American journal …, 2009 - journals.lww.com
Barrett esophagus (BE) is defined by the presence of metaplastic esophageal columnar
epithelium with goblet cells within endoscopically recognizable areas of the esophagus …

Unraveling the mystery of the gastroesophageal junction: a pathologist's perspective

RD Odze - Official journal of the American College of …, 2005 - journals.lww.com
The gastroesophageal junction (GEJ), which is defined as the point where the distal
esophagus joins the proximal stomach (cardia), is a short anatomic area that is commonly …

The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands

DL Lavery, AM Nicholson, R Poulsom, R Jeffery… - Gut, 2014 - gut.bmj.com
Objective Barrett's oesophagus shows appearances described as 'intestinal metaplasia', in
structures called 'crypts' but do not typically display crypt architecture. Here, we investigate …

Morphologic features are useful in distinguishing Barrett esophagus from carditis with intestinal metaplasia

A Srivastava, RD Odze, GY Lauwers… - The American journal …, 2007 - journals.lww.com
Barrett esophagus (BE) and carditis with intestinal metaplasia (CIM) differ in their risk of
malignancy and implications for patient management, but are difficult to distinguish in …

The role of mucin in GERD and its complications

Y Niv, R Fass - Nature reviews Gastroenterology & hepatology, 2012 - nature.com
Acid, pepsin and other noxious material reach the esophageal mucosa and interact with the
luminal aspect of the squamous epithelium. The first protective barrier to these potentially …

MUC2 is a highly specific marker of goblet cell metaplasia in the distal esophagus and gastroesophageal junction

MG McIntire, G Soucy, TL Vaughan… - The American journal …, 2011 - journals.lww.com
Abstract Currently, the American College of Gastroenterology requires identification of
goblet cells in mucosal biopsies from the esophagus to diagnose Barrett esophagus (BE) …

Mechanisms of Barrett's oesophagus: intestinal differentiation, stem cells, and tissue models

H Nakagawa, K Whelan, JP Lynch - Best Practice & Research Clinical …, 2015 - Elsevier
Barrett's oesophagus (BE) is defined as any metaplastic columnar epithelium in the distal
oesophagus which replaces normal squamous epithelium and which predisposes to cancer …

Microscopic esophagitis and Barrett's esophagus: the histology report

R Fiocca, L Mastracci, M Milione, P Parente… - Digestive and Liver …, 2011 - Elsevier
Gastro-esophageal reflux disease (GERD) is the most common digestive disease in
industrialized countries (Europe and North America) and is associated with microscopic …