Although chronological age correlates with various age‐related diseases and conditions, it
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Aging is a leading risk factor for cancer. While it is proposed that age-related accumulation
of somatic mutations drives this relationship, it is likely not the full story. We show that aging …

Stress triggers anticipatory physiological responses that promote survival, a phenomenon
termed allostasis. However, the chronic activation of energy-dependent allostatic responses …

Individuals with psychiatric disorders are at increased risk of age-related diseases and early
mortality. Recent studies demonstrate that this link between mental health and aging is …

Age-related changes in DNA methylation (DNAm) form the basis of the most robust
predictors of age—epigenetic clocks—but a clear mechanistic understanding of exactly …

Population aging is an irreversible process in the development of modern society, which
brings challenges to comprehensive modernized social governance. Population aging is a …

Aging is a process that affects almost all multicellular organisms and since our population
ages with increasing prevalence of age-related diseases, it is important to study basic …

Biological aging is characterized by irreversible cell cycle blockade, a decreased capacity
for tissue regeneration, and an increased risk of age-related diseases and mortality. A …

A vast body of studies is available that describe age-dependent gene expression in relation
to aging in a number of different model species. These data were obtained from animals …