Aggregation of specific proteins are histopathological hallmarks of several
neurodegenerative diseases, such as, Amyloid β (Aβ) plaques and tau neurofibrillary …

Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

A pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-β (Aβ)
protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD …

The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

An extensive electrophysiological literature has proposed a pathological 'slowing'of
neuronal activity in patients on the Alzheimer's disease spectrum. Supported by numerous …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily affecting
cognitive functions. However, sensory deficits in AD start to draw attention due to their high …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the
accumulation of amyloid-beta (Aβ) peptides in the brain. Among the different forms of Aβ …

Protein aggregation likely plays a key role in the initiation and spreading of Alzheimer's
disease pathology through the brain. Soluble aggregates of amyloid beta are believed to …

The accumulation of amyloid-β protein (Aβ) plays an early role in the pathogenesis of
Alzheimer's disease (AD). The precise mechanism of how Aβ accumulation leads to synaptic …

The locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …