Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

The roles of serotonin in neuropsychiatric disorders

M Pourhamzeh, FG Moravej, M Arabi… - Cellular and molecular …, 2022 - Springer
The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …

Social circuits and their dysfunction in autism spectrum disorder

M Sato, N Nakai, S Fujima, KY Choe, T Takumi - Molecular Psychiatry, 2023 - nature.com
Social behaviors, how individuals act cooperatively and competitively with conspecifics, are
widely seen across species. Rodents display various social behaviors, and many different …

Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse

KY Choe, RAI Bethlehem, M Safrin, H Dong, E Salman… - Neuron, 2022 - cell.com
The neural basis of abnormal social behavior in autism spectrum disorders (ASDs) remains
incompletely understood. Here we used two complementary but independent brain-wide …

Neural circuits regulating prosocial behaviors

JJ Walsh, DJ Christoffel, RC Malenka - Neuropsychopharmacology, 2023 - nature.com
Positive, prosocial interactions are essential for survival, development, and well-being.
These intricate and complex behaviors are mediated by an amalgamation of neural circuit …

The synaptic and circuit functions of vitamin D in neurodevelopment disorders

X Ye, Q Zhou, P Ren, W Xiang… - … Disease and Treatment, 2023 - Taylor & Francis
Vitamin D deficiency/insufficiency is a public health issue around the world. According to
epidemiological studies, low vitamin D levels have been associated with an increased risk of …

Lifelong Exposure to a Low-Dose of the Glyphosate-Based Herbicide RoundUp® Causes Intestinal Damage, Gut Dysbiosis, and Behavioral Changes in Mice

I Del Castilo, AS Neumann, FS Lemos… - International Journal of …, 2022 - mdpi.com
RoundUp®(RUp) is a comercial formulation containing glyphosate (N-(phosphono-methyl)
glycine), and is the world's leading wide-spectrum herbicide used in agriculture. Supporters …

Awake functional MRI detects neural circuit dysfunction in a mouse model of autism

T Tsurugizawa, K Tamada, N Ono, S Karakawa… - Science …, 2020 - science.org
MRI has potential as a translational approach from rodents to humans. However, given that
mouse functional MRI (fMRI) uses anesthetics for suppression of motion, it has been difficult …

From plants to psycho-neurology: unravelling the therapeutic benefits of bioactive compounds in brain disorders

C Grosso, M Santos, MF Barroso - Antioxidants, 2023 - mdpi.com
The brain's sensitivity to oxidative stress and neuronal cell death requires effective
pharmacotherapy approaches. Current pharmacological therapies are frequently ineffective …

DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopmental disorders

DL Christian, DY Wu, JR Martin, JR Moore, YR Liu… - Cell Reports, 2020 - cell.com
Mutations in DNA methyltransferase 3A (DNMT3A) have been detected in autism and
related disorders, but how these mutations disrupt nervous system function is unknown …