Thrombocytopathy vs Platelet hyper-reactivity in COVID-19: diverse pathologies, disease outcomes and therapeutic implications

A Tafazoli, S Anil Kumar, M Othman - Platelets, 2022 - Taylor & Francis
Coagulopathy is an evident complication of COVID-19 with predominance of a
prothrombotic state. Platelet activation plays a key role. The terms “hyper-reactivity” and …

Coagulation abnormalities and clinical complications in children with SARS-CoV-2: a systematic review of 48,322 patients

CG McDaniel, SJ Commander, I DeLaura… - Journal of pediatric …, 2022 - journals.lww.com
Given the limited information on the coagulation abnormalities of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) in pediatric patients, we designed a systematic …

Chronic Oral Anticoagulation Therapy and Prognosis of Patients Admitted to Hospital for COVID‐19: Insights from the HOPE COVID‐19 Registry

JM Rivera-Caravaca, IJ Núñez-Gil… - … journal of clinical …, 2022 - Wiley Online Library
Background. Most evidence regarding anticoagulation and COVID‐19 refers to the
hospitalization setting, but the role of oral anticoagulation (OAC) before hospital admission …

Efficacy and safety of regdanvimab in patients with mild to moderate COVID‐19: A rapid review and meta‐analysis

B Amani, B Amani - British Journal of Clinical Pharmacology, 2023 - Wiley Online Library
Aims This study aimed to evaluate the efficacy and safety of regdanvimab, an anti‐SARS‐
COV‐2 monoclonal antibody approved by the European Medicines Agency in November …

[HTML][HTML] Efficacy and limitations of repurposed drugs and vaccines for COVID-19

N Murmu, M Sarkar, S Dey, R Manna, S Roy… - Journal of Medicine …, 2023 - Elsevier
ABSTRACT COVID-19 is a contagious, severe acute respiratory disease caused by the
coronavirus named SARS-CoV-2. In this review, we have updated the nature and evolution …

Unlike RNA-TBA (rTBA), iso-rTBA, the 2′–5′-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA

AA Wagh, VA Kumar, S Ravindranathan… - Chemical …, 2023 - pubs.rsc.org
An antiparallel, functional RNA G-quadruplex of the 2′–5′-linked thrombin-binding
aptamer (iso-rTBA) is reported for the first time. It can inhibit clotting and is remarkably stable …

Bile Acids and SARS-CoV-2: Ursodeoxycholic Acid as a Potential Treatment of COVID-19

S Fiorucci, G Urbani, E Distrutti - Recent Advances in …, 2023 - ingentaconnect.com
Since the beginning of the COVID-19 pandemic in 2020, as of 5: 35 pm CET, 10th February,
2023, there have been 755.385. 709 confirmed cases of COVID-19, including 6.833. 388 …

[HTML][HTML] A snake venom-analog peptide that inhibits SARS-CoV-2 and papain-like protease displays antithrombotic activity in mice arterial thrombosis model, without …

RS Nogueira, BR Salu, VG Nardelli, CR Bonturi… - Thrombosis …, 2023 - Springer
Abstract Background (p-BthTX-I) 2 K, a dimeric analog peptide derived from the C-terminal
region of phospholipase A2-like bothropstoxin-I (p-BthTX-I), is resistant to plasma …

[HTML][HTML] A population pharmacokinetic model of remdesivir and its major metabolites based on published mean values from healthy subjects

A Abouellil, M Bilal, M Taubert, U Fuhr - Naunyn-schmiedeberg's Archives …, 2023 - Springer
Remdesivir is a direct-acting anti-viral agent. It was originally evaluated against filoviruses.
However, during the COVID-19 pandemic, it was investigated due to its anti-viral activities …

[HTML][HTML] Guidelines for reopening a nation in a SARS-CoV-2 pandemic: A path forward

TL Baker, JV Greiner - Medicina, 2021 - mdpi.com
Background and Objectives: Action, not fear, is the path forward in the coronavirus infectious
disease 2019 (COVID-19) pandemic. Since early 2020, the world's nations have faced …