Uncovering sex differences of rodent microglia

J Han, Y Fan, K Zhou, K Blomgren… - Journal of …, 2021 - Springer
There are inherent structural and functional differences in the central nervous systems
(CNS) of females and males. It has been gradually established that these sex-specific …

Sex differences: Transcriptional signatures of stress exposure in male and female brains

E Brivio, JP Lopez, A Chen - Genes, brain and behavior, 2020 - Wiley Online Library
More than two‐thirds of patients suffering from stress‐related disorders are women but over
two‐thirds of suicide completers are men. These are just some examples of the many sex …

Democratizing knowledge representation with BioCypher

S Lobentanzer, P Aloy, J Baumbach, B Bohar… - Nature …, 2023 - nature.com
Biomedical data are amassed at an ever-increasing rate, and machine learning tools that
use prior knowledge in combination with biomedical big data are gaining much traction 1, 2 …

[HTML][HTML] Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for …

PN Pallier, M Ferrara, F Romagnolo, MT Ferretti… - Progress in …, 2022 - Elsevier
Neurological and neuropsychiatric disorders affect men and women differently. Multiple
sclerosis, Alzheimer's disease, anxiety disorders, depression, meningiomas and late-onset …

Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults

Z Kovarik, G Moshitzky, N Maček Hrvat… - Journal of …, 2024 - Wiley Online Library
This review presents recent studies of the chemical and molecular regulators of
acetylcholine (ACh) signaling and the complexity of the small molecule and RNA regulators …

Regulators of cholinergic signaling in disorders of the central nervous system

K Winek, H Soreq, A Meisel - Journal of Neurochemistry, 2021 - Wiley Online Library
Cholinergic signaling is crucial in cognitive processes, and degenerating cholinergic
projections are a pathological hallmark in dementia. Use of cholinesterase inhibitors is …

Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade

K Winek, S Lobentanzer, B Nadorp… - Proceedings of the …, 2020 - National Acad Sciences
Stroke is a leading cause of death and disability. Recovery depends on a delicate balance
between inflammatory responses and immune suppression, tipping the scale between brain …

[HTML][HTML] The neat dance of COVID-19: NEAT1, DANCR, and co-modulated cholinergic RNAs link to inflammation

C Meydan, N Madrer, H Soreq - Frontiers in immunology, 2020 - frontiersin.org
The COVID-19 pandemic exerts inflammation-related parasympathetic complications and
post-infection manifestations with major inter-individual variability. To seek the …

Differential expression of miR-148b, miR-129-2 and miR-296 in animal models of schizophrenia-Relevance to NMDA receptor hypofunction

S Gunasekaran, RS Jacob, RV Omkumar - Neuropharmacology, 2022 - Elsevier
Hypofunction of N-methyl-d-aspartate receptors (NMDAR) is a key component in the
pathophysiology of schizophrenia. Alterations in the regulation of NMDARs by microRNAs …

Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex, and Parkinson's disease‐related changes

I Paldor, N Madrer, S Vaknine Treidel… - Journal of …, 2023 - Wiley Online Library
Transfer RNA fragments (tRFs) have recently been shown to be an important family of small
regulatory RNAs with diverse functions. Recent reports have revealed modified tRF blood …